Purpose <p>This study assessed airborne atrazine concentrations in selected urban and farming communities and the non-carcinogenic inhalation risks for residents. The main research question examined whether ambient atrazine concentrations pose potential health risks under different exposure settings.</p> Methods <p>A total of 40 airborne particulate matter samples were collected using pre-mounted filter papers and a Sibata Low Volume Air Sampler (Model LV- 40) at a flow rate of 30&#xa0;L/min over 8&#xa0;h periods. Atrazine was extracted using acetonitrile and ultrasonication and analyzed with High-Performance Liquid Chromatography with UV detection (HPLC-UV), using an autosampler (model 410 Varian, USA).</p> Results <p>Atrazine concentrations in urban areas were generally low, ranging from 0.28 ± 0.55 pg/m³ in Suame and Gyinyase, 0.29 ± 0.55 pg/m³ in Buokrom Estate, 0.53 ± 1.05 pg/m³ in Tanoso, to 1.05 ± 2.10 pg/m³ in Kejetia. In contrast, relatively higher concentrations were observed in the farming areas: 12.72 ± 7.69 pg/m³ in Nkawie-Toase, 13.34 ± 10.70 pg/m³ in Afari, and 16.48 ± 17.17 pg/m³ in Mpasatia. All measured concentrations were below the acceptable daily intake of 2.00 E + 07 pg/m³ for inhalation. Risk quotient values were also below the threshold of concern, suggesting minimal non-carcinogenic health effects.</p> Conclusion <p>Although atrazine levels are within the regulatory limits, continuous exposure may pose potential risks to children in farming communities. Although limited by a small sample size and consideration of only the inhalation pathway, this study provides valuable baseline data on airborne atrazine exposure in Ghana. It emphasizes the need for improved pesticide management practices and regular monitoring of airborne contaminants in agricultural settings.</p>