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<p>Amphiphilic polymers have attracted significant interest due to their versatile applications in the biomedical, pharmaceutical, and cosmetic fields. In this work, we report the synthesis of novel cationic comb-shaped polymers derived from <i>N</i>,<i> N</i>-dimethylaminoethyl acrylate (MDMAEA) through free radical polymerization. The obtained polymers were thoroughly characterized using Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (<sup>1</sup>H NMR), and viscosimetric analysis to confirm their structural features and evaluate their solution behavior. In aqueous and hydro-alcoholic media, amphiphilic polymers are known to undergo self-assembly processes driven by the balance between hydrophilic and hydrophobic interactions. To investigate this phenomenon, a detailed viscosimetric study was performed on the synthesized polymers. The results revealed that the reduced viscosity of polymer solutions decreases as the concentration increases, indicating the predominance of intramolecular associations. This behavior is attributed to the hydrophobic interactions of the side alkyl chains, which induce polymer chain folding and reduce intermolecular entanglements. Such behavior is consistent with the general characteristics of polysoaps, highlighting their ability to form micelle-like structures in selective solvents. The findings of this study provide valuable insights into the self-organization of comb-shaped polymers in solution, which is essential for tailoring their physicochemical properties and optimizing their performance in drug delivery, surface modification, and other advanced applications.Based on the optical spectra, the composite has an optical bandgap energy, E<sub>g</sub> = 3.15&#xa0;eV. The energy gap results can confirm the behavior of a semiconductor. The polymers PDMAEAC<sub>6</sub> and PDMAEAC<sub>10</sub> exhibited strong antimicrobial activity against both bacteria and fungi, likely through membrane disruption via electrostatic interactions, making them promising candidates for biomedical and topical use.</p>

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Comb-Shaped Amphiphilic Polysoaps: Structural Characterization, Solution Behavior, and Antimicrobial Activity

  • 期刊论文

  • 发表日期：

    2026年2月23日

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  • Wahiba Chaibi,
  • Lamia Bennabi,
  • Bekhti Nabila,
  • Asma Ghali,
  • Kaddour Guemra,
  • Abdelkader Dehbi,
  • Massimo Messori,
  • Ali Alsalme

摘要

Amphiphilic polymers have attracted significant interest due to their versatile applications in the biomedical, pharmaceutical, and cosmetic fields. In this work, we report the synthesis of novel cationic comb-shaped polymers derived from N, N-dimethylaminoethyl acrylate (MDMAEA) through free radical polymerization. The obtained polymers were thoroughly characterized using Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR), and viscosimetric analysis to confirm their structural features and evaluate their solution behavior. In aqueous and hydro-alcoholic media, amphiphilic polymers are known to undergo self-assembly processes driven by the balance between hydrophilic and hydrophobic interactions. To investigate this phenomenon, a detailed viscosimetric study was performed on the synthesized polymers. The results revealed that the reduced viscosity of polymer solutions decreases as the concentration increases, indicating the predominance of intramolecular associations. This behavior is attributed to the hydrophobic interactions of the side alkyl chains, which induce polymer chain folding and reduce intermolecular entanglements. Such behavior is consistent with the general characteristics of polysoaps, highlighting their ability to form micelle-like structures in selective solvents. The findings of this study provide valuable insights into the self-organization of comb-shaped polymers in solution, which is essential for tailoring their physicochemical properties and optimizing their performance in drug delivery, surface modification, and other advanced applications.Based on the optical spectra, the composite has an optical bandgap energy, Eg = 3.15 eV. The energy gap results can confirm the behavior of a semiconductor. The polymers PDMAEAC6 and PDMAEAC10 exhibited strong antimicrobial activity against both bacteria and fungi, likely through membrane disruption via electrostatic interactions, making them promising candidates for biomedical and topical use.