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<p>Breast cancer remains one of the leading causes of cancer-related mortality worldwide, necessitating the development of novel therapeutic strategies to improve treatment efficacy while minimizing systemic toxicity. Nanotechnology-based drug delivery systems offer a promising platform for targeted and controlled release of anticancer agents. The present study aimed to design and evaluate amine-functionalized hollow mesoporous silica nanoparticles (HMSN) as a nanocarrier system for the co-delivery of allyl sulfide (AS) and noscapine hydrochloride (NH) against breast cancer. ASNH-loaded HMSN were synthesized and systematically characterized using SEM, TEM, Particle size analysis, EDX, XRD, and FTIR spectroscopy. Drug-loading efficiency and release profiles were assessed under acidic and neutral pH conditions. The anticancer potential of the drug-loaded nanoparticles was evaluated in vitro against MCF-7 breast cancer cells through cytotoxicity, apoptosis induction, and migration inhibition assays. The formulated ASNH-HMSN were monodispersed, spherical, and exhibited a diameter of 153&#xa0;nm. Elemental and spectroscopic analyses of ASNH-HMSN confirmed successful surface functionalization and ASNH incorporation, with high drug-loading efficiency (87.92%). The ASNH-HMSN demonstrated pH-responsive sustained release, with cumulative drug release of 92.78% in acidic and 65.74% in neutral environments. In vitro studies revealed enhanced cytotoxicity with a reduced IC<sub>50</sub> value (45.1 µM), along with significantly increased apoptosis induction and inhibition of cell migration compared to free drugs. These findings underscore the potential of ASNH-loaded HMSN as an efficient and targeted nanoplatform for breast cancer treatment.</p>

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Therapeutic Potential of Allyl Sulfide-noscapine Hydrochloride Combination-loaded Hollow Mesoporous Silica Nanoparticles in Breast Cancer MCF-7 Cells

  • 期刊论文

  • 发表日期：

    2025年10月28日

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  • Chitradevi Kaniraja,
  • Azar Zochedh,
  • Kaliraj Chandran,
  • Sureba Sukumaran,
  • Thimma Mohan Viswanathan,
  • Asath Bahadur Sultan,
  • Thandavarayan Kathiresan

摘要

Breast cancer remains one of the leading causes of cancer-related mortality worldwide, necessitating the development of novel therapeutic strategies to improve treatment efficacy while minimizing systemic toxicity. Nanotechnology-based drug delivery systems offer a promising platform for targeted and controlled release of anticancer agents. The present study aimed to design and evaluate amine-functionalized hollow mesoporous silica nanoparticles (HMSN) as a nanocarrier system for the co-delivery of allyl sulfide (AS) and noscapine hydrochloride (NH) against breast cancer. ASNH-loaded HMSN were synthesized and systematically characterized using SEM, TEM, Particle size analysis, EDX, XRD, and FTIR spectroscopy. Drug-loading efficiency and release profiles were assessed under acidic and neutral pH conditions. The anticancer potential of the drug-loaded nanoparticles was evaluated in vitro against MCF-7 breast cancer cells through cytotoxicity, apoptosis induction, and migration inhibition assays. The formulated ASNH-HMSN were monodispersed, spherical, and exhibited a diameter of 153 nm. Elemental and spectroscopic analyses of ASNH-HMSN confirmed successful surface functionalization and ASNH incorporation, with high drug-loading efficiency (87.92%). The ASNH-HMSN demonstrated pH-responsive sustained release, with cumulative drug release of 92.78% in acidic and 65.74% in neutral environments. In vitro studies revealed enhanced cytotoxicity with a reduced IC50 value (45.1 µM), along with significantly increased apoptosis induction and inhibition of cell migration compared to free drugs. These findings underscore the potential of ASNH-loaded HMSN as an efficient and targeted nanoplatform for breast cancer treatment.