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Purpose <p>Amaranthaceae species have garnered considerable attention due to their diverse pharmacological and biological properties. One specific species, <i>Haloxylon persicum</i> Bunge, is an exotic species that was accidentally introduced to the Saharan zone of Nefzaoua in southern Tunisia, North Africa. This species is known for its pharmacological and biological properties.</p> Methods <p>This study used liquid chromatography-tandem mass spectrometry (LC-HESI-MS<sup>2</sup>) to detect alkaloid metabolites in the total alkaloids extract. The phytochemical composition (total polyphenol, flavonoid, and tannin contents) and biological activities, specifically the antioxidant and antibacterial properties of the leaf extracts of <i>Haloxylon persicum</i> Bunge were assessed.</p> Results <p>The total alkaloid extract revealed the presence of 37 chemicals, from which we identified 28 compounds, with 46.43% identified as alkaloids, including anabasine, haloxine, and taxinine. <i>Haloxylon persicum</i> exhibited potent antioxidant activity in multiple tests (DPPH, ABTS, TAC, and FRAP). Acid-base treatment of the hydroethanolic extract significantly enhanced its antimicrobial activity, surpassing that of the crude extract, especially, the total alkaloid and butanolic extracts.</p> Conclusion <p><i>Haloxylon persicum</i> and its alkaloid-derived secondary metabolites showed potential for medicinal applications and the management of pathogenic microorganisms.</p>

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Mass Spectrometry-Based Metabolomic Analysis and Biological Activities of Alkaloids from Haloxylon Persicum Bunge Leaves Extracts

  • 期刊论文

  • 发表日期：

    2025年10月23日

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  • Hanen Farhat,
  • Bouthaina Bouzayani,
  • Ameni ben Ammar,
  • Nathan Téné,
  • Ines Hadrich,
  • Michel Treilhou,
  • Raoudha Mezghani-Jarraya,
  • Mohamed Trigui,
  • Mohamed Chaieb,
  • Mariam Siala

摘要

Purpose

Amaranthaceae species have garnered considerable attention due to their diverse pharmacological and biological properties. One specific species, Haloxylon persicum Bunge, is an exotic species that was accidentally introduced to the Saharan zone of Nefzaoua in southern Tunisia, North Africa. This species is known for its pharmacological and biological properties.

Methods

This study used liquid chromatography-tandem mass spectrometry (LC-HESI-MS2) to detect alkaloid metabolites in the total alkaloids extract. The phytochemical composition (total polyphenol, flavonoid, and tannin contents) and biological activities, specifically the antioxidant and antibacterial properties of the leaf extracts of Haloxylon persicum Bunge were assessed.

Results

The total alkaloid extract revealed the presence of 37 chemicals, from which we identified 28 compounds, with 46.43% identified as alkaloids, including anabasine, haloxine, and taxinine. Haloxylon persicum exhibited potent antioxidant activity in multiple tests (DPPH, ABTS, TAC, and FRAP). Acid-base treatment of the hydroethanolic extract significantly enhanced its antimicrobial activity, surpassing that of the crude extract, especially, the total alkaloid and butanolic extracts.

Conclusion

Haloxylon persicum and its alkaloid-derived secondary metabolites showed potential for medicinal applications and the management of pathogenic microorganisms.