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<p>Researchers and health authorities in several countries are trying to formulate new medicines and action plans to solve the antimicrobial resistance (AMR) problem. Due to non-toxicity, chemical stability, low cost, photocatalytic properties, and GRAS (Generally Recognized as Safe) status, TiO<sub>2</sub> (titanium dioxide) in particular, has been regarded as an appealing antibacterial molecule. Additionally, TiO<sub>2</sub> nanoparticles promote the inactivation of microbes due to their potent oxidizing capability by producing free radicals, including hydroxyl and superoxide anion radicals, which exhibit reduced growth against a variety of microbes like <i>E.coli</i> and <i>S. aureus</i>. In this review, several synthesis and characterization processes of TiO<sub>2</sub> nanoparticles have been discussed in detail which can help in the development of the simplest route of synthesis with the most cost-effectiveness. The mechanism of action of TiO<sub>2</sub> nanoparticles to inhibit the growth of microorganisms and its application in targeted drug delivery are the second most important purpose of this paper. Finally, a path through which future research on these nanoparticles can be developed has also been indicated. This review may help the researcher to find a new route for the facile, simple, and cost-effective development of a new antimicrobial agent with TiO<sub>2</sub> as the base material.</p>

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Review on Synthesis and Characterization of TiO2 Nanoparticles: A Potent Antimicrobial and Drug Delivery Agent

  • 期刊论文

  • 发表日期：

    2025年8月22日

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  • Moupiya Ghosh,
  • Chandan Ghorui,
  • Susomoy Datta,
  • Anindya Roy,
  • Avijit Tudu,
  • Samir Mandal,
  • Soumyajit Sarkar,
  • Anil Kumar Chaudhary

摘要

Researchers and health authorities in several countries are trying to formulate new medicines and action plans to solve the antimicrobial resistance (AMR) problem. Due to non-toxicity, chemical stability, low cost, photocatalytic properties, and GRAS (Generally Recognized as Safe) status, TiO2 (titanium dioxide) in particular, has been regarded as an appealing antibacterial molecule. Additionally, TiO2 nanoparticles promote the inactivation of microbes due to their potent oxidizing capability by producing free radicals, including hydroxyl and superoxide anion radicals, which exhibit reduced growth against a variety of microbes like E.coli and S. aureus. In this review, several synthesis and characterization processes of TiO2 nanoparticles have been discussed in detail which can help in the development of the simplest route of synthesis with the most cost-effectiveness. The mechanism of action of TiO2 nanoparticles to inhibit the growth of microorganisms and its application in targeted drug delivery are the second most important purpose of this paper. Finally, a path through which future research on these nanoparticles can be developed has also been indicated. This review may help the researcher to find a new route for the facile, simple, and cost-effective development of a new antimicrobial agent with TiO2 as the base material.