Scholarlink

<p>The green synthesized Zinc oxide nanoparticles (ZnO-NPs) are highly promising as antimicrobial and anticancer agents, due to their stability, safety, and biological, chemical, and physical properties. This study aimed to investigate the biosynthesized ZnO-NPs using <i>Hibiscus</i> and <i>Mentha</i> extracts as antibacterial and anticancer agents. The results in this work showed that the formation of ZnO-NPs using <i>Hibiscus</i> extract (Hi-ZnO-NPs) was with a size range of 15–20&#xa0;nm while <i>Mentha</i> extract (Me-ZnO-NPs) was about 20–50&#xa0;nm by transmission Electron Microscopy (TEM). Further, irregular shapes, agglomeration, and some coagulation were observed by Scanning Electron Microscopy (SEM). Both Me-ZnO-NPs and Hi-ZnO-NPs showed a surface plasmon absorption at 355 and 372&#xa0;nm, respectively. Both ZnO-NPs have pure components with high carbon content for Hi-ZnO-NPs, Zinc 36.2%, oxygen 40.6%, and carbon 23.1%, and Me-ZnO-NPs, Zinc 68.6%, oxygen 22.5%, and carbon 7.5%. The bacteriostatic against Gram-positive and Gram-negative bacteria was highly significant in log<sub>10</sub> difference for both formulated ZnO-NPs. For the cytotoxicity, Hi-ZnO-NPs exhibited 50% cytotoxic concentration (CC<sub>50</sub>) against MCF7 and HepG2, equal to 60.59 and 123.76&#xa0;µg/mL, respectively. While the CC<sub>50</sub> for Me-ZnO-NPs was 82.28&#xa0;µg/mL for MCF-7, 69.36&#xa0;µg/mL for HepG2. Moreover, both Hi-ZnO-NPs and Me-ZnO-NPs showed a safety effect on a normal cell line (HSF), with CC<sub>50</sub> of &gt; 1000&#xa0;µg/mL. In conclusion, the data from this work highlight the ability to use ZnO-NPs as bacteriostatic and potential anticancer compounds.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Characterization, Antibacterial, and Anticancer Activity of Biosynthesized Zinc Oxide Nanoparticles (ZnO-NPs) Using Hibiscus and Mentha Extracts

  • 期刊论文

  • 发表日期：

    2025年8月13日

查看全文
  • Azza G. Kamel,
  • Abdallah S. Abdelsattar,
  • Aghapy Yermans Yakoup,
  • Hassan Gamal,
  • Yasmin Elbermawy,
  • Ayman El-Shibiny

摘要

The green synthesized Zinc oxide nanoparticles (ZnO-NPs) are highly promising as antimicrobial and anticancer agents, due to their stability, safety, and biological, chemical, and physical properties. This study aimed to investigate the biosynthesized ZnO-NPs using Hibiscus and Mentha extracts as antibacterial and anticancer agents. The results in this work showed that the formation of ZnO-NPs using Hibiscus extract (Hi-ZnO-NPs) was with a size range of 15–20 nm while Mentha extract (Me-ZnO-NPs) was about 20–50 nm by transmission Electron Microscopy (TEM). Further, irregular shapes, agglomeration, and some coagulation were observed by Scanning Electron Microscopy (SEM). Both Me-ZnO-NPs and Hi-ZnO-NPs showed a surface plasmon absorption at 355 and 372 nm, respectively. Both ZnO-NPs have pure components with high carbon content for Hi-ZnO-NPs, Zinc 36.2%, oxygen 40.6%, and carbon 23.1%, and Me-ZnO-NPs, Zinc 68.6%, oxygen 22.5%, and carbon 7.5%. The bacteriostatic against Gram-positive and Gram-negative bacteria was highly significant in log10 difference for both formulated ZnO-NPs. For the cytotoxicity, Hi-ZnO-NPs exhibited 50% cytotoxic concentration (CC50) against MCF7 and HepG2, equal to 60.59 and 123.76 µg/mL, respectively. While the CC50 for Me-ZnO-NPs was 82.28 µg/mL for MCF-7, 69.36 µg/mL for HepG2. Moreover, both Hi-ZnO-NPs and Me-ZnO-NPs showed a safety effect on a normal cell line (HSF), with CC50 of > 1000 µg/mL. In conclusion, the data from this work highlight the ability to use ZnO-NPs as bacteriostatic and potential anticancer compounds.