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<p>Natural plant extracts have been extensively explored in traditional medicine for their therapeutic potential, including the treatment of tuberculosis (TB), due to their diverse bioactive compounds. <i>Andrographis paniculata</i>, recognized for its antimicrobial and immunomodulatory properties, is considered a promising candidate for developing anti-tuberculosis agents. This study investigated the antimycobacterial activity of <i>A. paniculata</i> extracts and the isolated compound neoandrographolide against <i>Mycobacterium tuberculosis</i> H<sub>37</sub>Rv and multidrug-resistant (MDR) strains. The hexane, chloroform, and methanol extracts were evaluated using the microbroth dilution assay, with the methanol extract exhibiting a significant Minimum Inhibitory Concentration (MIC) of 250&#xa0;µg/mL against the H<sub>37</sub>Rv strain. Further testing of neoandrographolide revealed its potent activity, achieving complete inhibition of H<sub>37</sub>Rv at 62.5&#xa0;µg/mL and demonstrating efficacy against MDR isolates at MICs of 250&#xa0;µg/mL, 125&#xa0;µg/mL, and 500&#xa0;µg/mL, respectively. These findings underscore the potential of neoandrographolide as a promising lead compound for developing novel anti-TB therapeutics, particularly for combating drug-resistant strains.</p>

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Potential of Neoandrographolide from Andrographis paniculata against Tuberculosis and Drug-Resistant Strains

  • 期刊论文

  • 发表日期：

    2025年7月4日

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  • Jelin Vilvest,
  • M. C. John Milton,
  • Alex Yagoo,
  • Kedike Balakrishna

摘要

Natural plant extracts have been extensively explored in traditional medicine for their therapeutic potential, including the treatment of tuberculosis (TB), due to their diverse bioactive compounds. Andrographis paniculata, recognized for its antimicrobial and immunomodulatory properties, is considered a promising candidate for developing anti-tuberculosis agents. This study investigated the antimycobacterial activity of A. paniculata extracts and the isolated compound neoandrographolide against Mycobacterium tuberculosis H37Rv and multidrug-resistant (MDR) strains. The hexane, chloroform, and methanol extracts were evaluated using the microbroth dilution assay, with the methanol extract exhibiting a significant Minimum Inhibitory Concentration (MIC) of 250 µg/mL against the H37Rv strain. Further testing of neoandrographolide revealed its potent activity, achieving complete inhibition of H37Rv at 62.5 µg/mL and demonstrating efficacy against MDR isolates at MICs of 250 µg/mL, 125 µg/mL, and 500 µg/mL, respectively. These findings underscore the potential of neoandrographolide as a promising lead compound for developing novel anti-TB therapeutics, particularly for combating drug-resistant strains.