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<p>A good and simple spectrophotometric method has been developed for the determination of dapsone by the dye bleaching method. The method depends on the oxidative bleaching of bromothymol blue dye using a mixture of (KBr + KBrO<sub>3</sub>) in the presence of hydrochloric acid, and then adding the dapsone. After completing the additions, the final product of the reaction (pink color) is formed, and then the absorption is measured at 518&#xa0;nm. In the concentration range of 2 to 10&#xa0;µg/mL, Beer’s law was observed, and the Sandell index was 0.0009&#xa0;µg.cm-2, while the molar absorbance was 2.6692 × 10<sup>3</sup> L. mol<sup>− 1</sup>. cm<sup>− 1</sup>. The quantitative limit was 0.1&#xa0;µg/mL, whereas the detection limit was 0.03&#xa0;µg/mL. Dapsone’s pharmaceutical formulation in tablet form was measured using this method, and the recovery percentage was 100.2% with a relative standard deviation of no more than 0.2%.</p> Graphical Abstract <p></p>

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A Simple Spectrophotometric Method for the Determination of Dapsone Using a Dye Bleaching Approach

  • 期刊论文

  • 发表日期：

    2025年6月6日

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  • Eman Thiab Al-Samarrai,
  • Menaa AbdulSalam Al-Abbasi,
  • Alaa Shayea Shubrem,
  • Rasha Saad Jwad,
  • Teba B. Ali,
  • Sabrean Farhan Jawad,
  • Mohammed S. S. Alyami,
  • Zamzam Alhuwaymil,
  • Sohad A. Alshareef,
  • Zainab S. Al-Sudani,
  • Mohammed H. Al-Mashhadani

摘要

A good and simple spectrophotometric method has been developed for the determination of dapsone by the dye bleaching method. The method depends on the oxidative bleaching of bromothymol blue dye using a mixture of (KBr + KBrO3) in the presence of hydrochloric acid, and then adding the dapsone. After completing the additions, the final product of the reaction (pink color) is formed, and then the absorption is measured at 518 nm. In the concentration range of 2 to 10 µg/mL, Beer’s law was observed, and the Sandell index was 0.0009 µg.cm-2, while the molar absorbance was 2.6692 × 103 L. mol− 1. cm− 1. The quantitative limit was 0.1 µg/mL, whereas the detection limit was 0.03 µg/mL. Dapsone’s pharmaceutical formulation in tablet form was measured using this method, and the recovery percentage was 100.2% with a relative standard deviation of no more than 0.2%.

Graphical Abstract