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Background <p>Cancer is a huge public health concern disproportionately impacting lives of affected individuals especially from the low- to middle-income countries. Current treatment options are either expensive or not sufficiently sustainable to reduce relapse rates. This gap has necessitated the search for novel compounds that can target molecular agents and ameliorate clinical symptoms. This study therefore aimed to identify novel phytochemicals with anticancer efficacy derived from <i>Hibiscus sabdariffa</i> using Gas Chromatography-Mass Spectrometry (GC-MS) technique and to analyse their in vitro antioxidant activities using standard methods.</p> Methods <p>Dried roselle leaves were washed, pulverized, and their ethanol extracts analysed for phytochemical composition and antioxidant activity. GC-MS was used to profile phytochemicals in the ethanol extract while 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing antioxidant power were employed to determine in vitro antioxidant properties.</p> Results <p>The analysis identified 27 phytochemicals in the ethanol extract of the plant with silymarin observed to exhibit highest concentration (16.8135 ppm), followed by naringin (14.5974 ppm), hesperidin (11.8788 ppm), epicatechin (11.7825 ppm), baicalin (8.6442 ppm) while others were found in smaller concentrations. The in vitro antioxidant analyses showed the plant to possess radical scavenging and ferric reduction abilities.</p> Conclusion <p>These findings validate the plant’s traditional applications and highlight its potential as a rich source of lead molecules for novel drug development in cancer therapeutics. However, research is needed to biosynthesize these bioactive compounds and further validate these studies in vivo and in clinical trials.</p>

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GC-MS Profiling and in Vitro Antioxidant Analysis Reveal Potential Small Molecule Phytocompounds Derived from Hibiscus sabdariffa for Cancer Management

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Uchechukwu Chibuzo Ogbodo,
  • Sylvia Oghenerukevwe Dafe

摘要

Background

Cancer is a huge public health concern disproportionately impacting lives of affected individuals especially from the low- to middle-income countries. Current treatment options are either expensive or not sufficiently sustainable to reduce relapse rates. This gap has necessitated the search for novel compounds that can target molecular agents and ameliorate clinical symptoms. This study therefore aimed to identify novel phytochemicals with anticancer efficacy derived from Hibiscus sabdariffa using Gas Chromatography-Mass Spectrometry (GC-MS) technique and to analyse their in vitro antioxidant activities using standard methods.

Methods

Dried roselle leaves were washed, pulverized, and their ethanol extracts analysed for phytochemical composition and antioxidant activity. GC-MS was used to profile phytochemicals in the ethanol extract while 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing antioxidant power were employed to determine in vitro antioxidant properties.

Results

The analysis identified 27 phytochemicals in the ethanol extract of the plant with silymarin observed to exhibit highest concentration (16.8135 ppm), followed by naringin (14.5974 ppm), hesperidin (11.8788 ppm), epicatechin (11.7825 ppm), baicalin (8.6442 ppm) while others were found in smaller concentrations. The in vitro antioxidant analyses showed the plant to possess radical scavenging and ferric reduction abilities.

Conclusion

These findings validate the plant’s traditional applications and highlight its potential as a rich source of lead molecules for novel drug development in cancer therapeutics. However, research is needed to biosynthesize these bioactive compounds and further validate these studies in vivo and in clinical trials.