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<p>The current research elucidates the solubilization characteristics of the non-polar medication Loratadine (LOR) within a mixed micellar solution comprising the non-ionic surfactants Tween-80 (TW-80) and Triton X-100 (TX-100) in conjunction with the cationic surfactant cetyltrimethylammonium bromide (CTAB). LOR surfactant interactions were examined using conductometry and simple and differential absorption spectroscopy. The partition coefficient (K<sub>x</sub>), binding constant (K<sub>b</sub>), free energy of binding (ΔG<sub>b</sub>), and free energy of partition (ΔG<sub>P</sub>) values were calculated to assess the effectiveness of the selected micellar system. Differential spectroscopy results showed that adding emulsifiers TX-100 and Tween-80 to the CTAB micellar system significantly increased the solubilization of LOR. The free energy of micellization (ΔGmic), the degree of dissociation (β), and micellization thermodynamic parameters have been determined using the conductometric response of micellar media. Apart from being enthalpy- and entropy-driven, the negative values of the enthalpy of micellization (ΔHmic) and free energy of micellization (ΔGmic) suggest that the dissolution of LOR in micelles was spontaneous. The quantitative measurement of LOR’s interaction with surfactant was obtained using UV-visible spectroscopy.</p>

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Micellar Encapsulation of Loratadine: Physiochemical Strategies for Improved Drug Solubility and Delivery

  • 期刊论文

  • 发表日期：

    2025年5月20日

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  • Iqra Shafi,
  • Mishayyam Ghaznavi,
  • Omar M. Ali,
  • Reham Yahya,
  • Afnan M. Alnajeebi,
  • Muhammad Babar Taj,
  • Ismat Bibi,
  • Tariq Javed,
  • Walla Alelwani

摘要

The current research elucidates the solubilization characteristics of the non-polar medication Loratadine (LOR) within a mixed micellar solution comprising the non-ionic surfactants Tween-80 (TW-80) and Triton X-100 (TX-100) in conjunction with the cationic surfactant cetyltrimethylammonium bromide (CTAB). LOR surfactant interactions were examined using conductometry and simple and differential absorption spectroscopy. The partition coefficient (Kx), binding constant (Kb), free energy of binding (ΔGb), and free energy of partition (ΔGP) values were calculated to assess the effectiveness of the selected micellar system. Differential spectroscopy results showed that adding emulsifiers TX-100 and Tween-80 to the CTAB micellar system significantly increased the solubilization of LOR. The free energy of micellization (ΔGmic), the degree of dissociation (β), and micellization thermodynamic parameters have been determined using the conductometric response of micellar media. Apart from being enthalpy- and entropy-driven, the negative values of the enthalpy of micellization (ΔHmic) and free energy of micellization (ΔGmic) suggest that the dissolution of LOR in micelles was spontaneous. The quantitative measurement of LOR’s interaction with surfactant was obtained using UV-visible spectroscopy.