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<p>In this research, Mesoporous silica KIT-6 nanoparticles were synthesized and functionalized through post-grafting method with (3-Aminopropyl) trimethoxysilane to form (KIT6-NH<sub>2</sub>) as a carrier for LOX loading and release. The synthesized materials were characterized using FTIR, XRD, N<sub>2</sub> physisorption, TEM, SEM, and TGA. The adsorption efficiency was studied by varying the carrier dosage, pH, LOX concentration, and contact time. The controlled release of LOX was examined using simulated enzymatic free gastric fluid pH (1.2) and intestinal fluid pH (7.4). The results showed that the loading efficiency of LOX by KIT6-NH<sub>2</sub> was 72.1% compared to a negligible value of bare KIT-6. In addition, the maximum adsorption capacity was 43.23&#xa0;mg/g using Langmuir isotherm. The remarkable improvement of LOX loading was due to the formation of robust bonding interaction between–NH<sub>2</sub> groups in KIT6-NH<sub>2</sub> and carbonyl groups in LOX. The release profile revealed a combination of initial burst release and prolonged sustained release, with the maximum LOX release of 61.95% at pH (7.4) compared to only 46.97% at pH (1.2). The release process follows the Higuchi kinetic model with a predominant diffusion mechanism. The cytotoxicity study proved that amino-modified KIT-6 is a biocompatible and non-toxic carrier, making it a promising drug delivery system in rheumatoid arthritis therapies.</p>

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Encapsulation of Lornoxicam Onto Amine Functionalized KIT-6 Nanoparticles as a Drug Delivery System for Rheumatoid Arthritis Therapy

  • 期刊论文

  • 发表日期：

    2025年4月8日

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  • Ali H. Khalbas,
  • Talib M. Albayati,
  • Majid S. Jabir,
  • Issam K. Salih

摘要

In this research, Mesoporous silica KIT-6 nanoparticles were synthesized and functionalized through post-grafting method with (3-Aminopropyl) trimethoxysilane to form (KIT6-NH2) as a carrier for LOX loading and release. The synthesized materials were characterized using FTIR, XRD, N2 physisorption, TEM, SEM, and TGA. The adsorption efficiency was studied by varying the carrier dosage, pH, LOX concentration, and contact time. The controlled release of LOX was examined using simulated enzymatic free gastric fluid pH (1.2) and intestinal fluid pH (7.4). The results showed that the loading efficiency of LOX by KIT6-NH2 was 72.1% compared to a negligible value of bare KIT-6. In addition, the maximum adsorption capacity was 43.23 mg/g using Langmuir isotherm. The remarkable improvement of LOX loading was due to the formation of robust bonding interaction between–NH2 groups in KIT6-NH2 and carbonyl groups in LOX. The release profile revealed a combination of initial burst release and prolonged sustained release, with the maximum LOX release of 61.95% at pH (7.4) compared to only 46.97% at pH (1.2). The release process follows the Higuchi kinetic model with a predominant diffusion mechanism. The cytotoxicity study proved that amino-modified KIT-6 is a biocompatible and non-toxic carrier, making it a promising drug delivery system in rheumatoid arthritis therapies.