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<p>A multifunctional theranostic agent for arterial embolization hyperthermia was developed. It combines magnetic hyperthermia and embolization ability together with the radiopacity in a single injectable formulation. The developed material represents a stable dispersion of iron oxide multicore particles in ethiodised oil, Lipiodol. The dispersion exhibited a rapid heating rate (19&#xa0;°C/min) and high specific loss power (42.0&#xa0;W/g) at clinically relevant alternating magnetic field, enabling therapeutic hyperthermia. It maintained low viscosity (&lt; 1&#xa0;Pa·s) under field-off conditions, allowing for efficient intra-tumoral or intra-arterial delivery. Upon the application of magnetic field (460 kA/m), the viscosity increased to approximately 4&#xa0;Pa·s, enabling embolization of tumor vasculature. The inherent radiopacity of Lipiodol, supported by the iron oxide, facilitates real-time image guidance during administration. The cytotoxicity studies, conducted by direct contact with the dispersion, revealed that the material is biocompatible up to a concentration of 0.05 wt%. The prepared Lipiodol-based dispersion of magnetic nanoparticles demonstrates strong potential for minimally invasive, image-guided arterial embolization hyperthermia.</p>

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Lipiodol-based magnetic multicore nanoparticle dispersion for image-guided arterial embolization hyperthermia

  • 期刊论文

  • 发表日期：

    2026年7月13日

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  • Ilona Smolková,
  • Natalia E. Kazantseva,
  • Zuzana Kroneková,
  • Markéta Ilčíková,
  • Miroslav Mrlík,
  • Pavol Šuly,
  • Filip Mikulka,
  • Jarmila Vilčáková,
  • Petr Smolka

摘要

A multifunctional theranostic agent for arterial embolization hyperthermia was developed. It combines magnetic hyperthermia and embolization ability together with the radiopacity in a single injectable formulation. The developed material represents a stable dispersion of iron oxide multicore particles in ethiodised oil, Lipiodol. The dispersion exhibited a rapid heating rate (19 °C/min) and high specific loss power (42.0 W/g) at clinically relevant alternating magnetic field, enabling therapeutic hyperthermia. It maintained low viscosity (< 1 Pa·s) under field-off conditions, allowing for efficient intra-tumoral or intra-arterial delivery. Upon the application of magnetic field (460 kA/m), the viscosity increased to approximately 4 Pa·s, enabling embolization of tumor vasculature. The inherent radiopacity of Lipiodol, supported by the iron oxide, facilitates real-time image guidance during administration. The cytotoxicity studies, conducted by direct contact with the dispersion, revealed that the material is biocompatible up to a concentration of 0.05 wt%. The prepared Lipiodol-based dispersion of magnetic nanoparticles demonstrates strong potential for minimally invasive, image-guided arterial embolization hyperthermia.