<p>A commercial cotton gauze bandage (CGB) is a thin, absorbent medical dressing material made of woven cotton fabrics, designed to dress wounds, absorb blood, and secretions, and protect against injuries. It is also used to secure other therapeutic ointments, promoting faster and cleaner healing, making it a common choice at homes and medical places. However, it is used alongside antibiotics (ointments) to prevent post-dressing infections and additional oral medications are also included to control pain and promote wound healing. Moreover, repetitive dressing causes mechanical debridement during removal and poses a challenge, often resulting in delayed healing. So, in this current research, we have surface-engineered a commercial cotton gauze bandage with bioactive agents to provide localized drug delivery, reduce local discomfort and minimize risk of infections following dressing application at a wound site. For this purpose, an electrospun mat of curcumin-loaded polycaprolactone-based nanofibers (Cu-PCL NFs) has been applied on top of the modified chitosan-coated cotton gauzes (CS-CG), which will subsequently provide antimicrobial properties by releasing loaded curcumin from the polycaprolactone (PCL) nanofibrous mat. The surface-modified dressing efficiently maintained the sterility of wound environment, reducing local pain by exhibiting anti-adhesive interaction with the wound bed. This was significantly evidenced by the low force requirement for its removal as compared to that of the commercial gauze. Additionally, this dressing provided an antibacterial, nanofibrous interface with sustained drug release that altogether promoted faster and infection-free healing process. This approach is designed for the development of a biomedical microdevice, offering potential benefits towards modern wound treatment, overcoming the traditional dressings improving patient outcomes.</p>