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<p>This study highlights the simple complex decomposition method to tune the magneto-structural properties of MnCoFe<sub>2</sub>O<sub>4</sub> (MnCoFe) NPs. The method successfully provides uniform, quasi-spherical MnCoFe (Mn = 0.1,0.2,0.3) magnetic nanoparticles (MNPs) with desired stoichiometry. Additionally, the optimized sample MnCoFe0.3 is characterized by XPS and EDX to analyze the chemical composition, distribution of Mn in the tetra and octahedral sites of CoFe<sub>2</sub>O<sub>4</sub> lattice and the stoichiometric composition of MNPs. The Mn doping significantly increases the magnetization (42.59 to 67.10 emu g<sup>− 1</sup>), SSA (26.86 to 79.27 m<sup>2</sup> g<sup>− 1</sup>) and microporosity (3.88 to 40.10%), which influences the properties desired for magnetic hyperthermia therapy (MHT). The induction heating studies determine the specific absorption rate (SAR) and intrinsic loss power (ILP) of the obtained MnCoFe0.1-0.3 MNPs at concentrations of 5 and 10&#xa0;mg mL-1. Sample MnCoFe0.3 (10&#xa0;mg mL<sup>− 1</sup>) shows the highest ΔT (37.4 ℃) with 50.73&#xa0;W g<sup>− 1</sup> of SAR at 26.7 kA m<sup>− 1</sup>. Mn substitution in CoFe₂O₄ attributes cation distribution and strengthens super-exchange interactions, enhances hyperthermia efficacy by increasing magnetic saturation and anisotropy, boosts specific loss power with improving the biocompatibility by reducing reactive Co<sup>2+</sup> exposure, resulting in negligible cytotoxicity in vitro/vivo applications examined using the Chorioallantoic Membrane Assay (CAM).</p> Graphical Abstract <p></p>

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Enhancing magnetic, structural, and heat generation properties of CoFe2O4 through Mn doping for potential application in magnetic hyperthermia therapy

  • 期刊论文

  • 发表日期：

    2026年3月9日

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  • Manohar Lad,
  • Rohant Dhabbe,
  • Prathamesh Chougale,
  • Pranoti Kamble,
  • Vidhya Jadhav,
  • Arpita Pandey-Tiwari,
  • Vishwajeet Khot,
  • Amit Supale,
  • Kiran Shinde,
  • Ki Buem Kim,
  • Sandip Sabale,
  • Deok-kee Kim

摘要

This study highlights the simple complex decomposition method to tune the magneto-structural properties of MnCoFe2O4 (MnCoFe) NPs. The method successfully provides uniform, quasi-spherical MnCoFe (Mn = 0.1,0.2,0.3) magnetic nanoparticles (MNPs) with desired stoichiometry. Additionally, the optimized sample MnCoFe0.3 is characterized by XPS and EDX to analyze the chemical composition, distribution of Mn in the tetra and octahedral sites of CoFe2O4 lattice and the stoichiometric composition of MNPs. The Mn doping significantly increases the magnetization (42.59 to 67.10 emu g− 1), SSA (26.86 to 79.27 m2 g− 1) and microporosity (3.88 to 40.10%), which influences the properties desired for magnetic hyperthermia therapy (MHT). The induction heating studies determine the specific absorption rate (SAR) and intrinsic loss power (ILP) of the obtained MnCoFe0.1-0.3 MNPs at concentrations of 5 and 10 mg mL-1. Sample MnCoFe0.3 (10 mg mL− 1) shows the highest ΔT (37.4 ℃) with 50.73 W g− 1 of SAR at 26.7 kA m− 1. Mn substitution in CoFe₂O₄ attributes cation distribution and strengthens super-exchange interactions, enhances hyperthermia efficacy by increasing magnetic saturation and anisotropy, boosts specific loss power with improving the biocompatibility by reducing reactive Co2+ exposure, resulting in negligible cytotoxicity in vitro/vivo applications examined using the Chorioallantoic Membrane Assay (CAM).

Graphical Abstract