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<p>An important factor in the success of a periodontal regeneration membrane is its ability to withstand the mechanical stress of periodontal regeneration surgery and osteoblast cell activity for growth and differentiation in producing the bone matrix. Bioactive glass (BG), i.e., silicate-based bioceramics, can facilitate the healing of bone tissue. BG interacts with body fluids, forming a calcium-phosphate layer, crucial for implant integration. Polyvinyl alcohol (PVA)–chitosan (CS) blends are non-toxic, biodegradable, and biocompatible. PVA-CS was combined with BG for mechanical strengthening and to improve osteoblast cell activity. BG powders possess nanometric and open pores, as determined via transmission electron microscopy and a Brunauer–Emmett–Teller porosimetric analyzer. The ultimate tensile strength and elastic modulus of BG/PVA-CS films increased with the content of BG. PVA-CS films with 4% BG have an ultimate tensile strength of 1.13 ± 0.23&#xa0;MPa, an improvement of 246% compared to PVA-CS films. The cell proliferation and alkaline phosphatase (ALP) activity of PVA-CS films were significantly increased after BG supplementation. In this study, a film with moderate tensile strength was pro-posed as a periodontal regeneration membrane that resists mechanical stress and facilitates the healing of bone tissue after periodontal regeneration surgery.</p>

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Addition of bioglass particles to flexible polyvinyl alcohol–chitosan hydrogel films strengthens their mechanical properties and osteoblast cell activity

  • 期刊论文

  • 发表日期：

    2025年5月20日

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  • Tzer-Min Lee,
  • Ken-Chung Chen,
  • Yu-Chen Lu,
  • Chia-Jung Cheng,
  • Hsun-Yu Huang,
  • Chih-Ling Huang

摘要

An important factor in the success of a periodontal regeneration membrane is its ability to withstand the mechanical stress of periodontal regeneration surgery and osteoblast cell activity for growth and differentiation in producing the bone matrix. Bioactive glass (BG), i.e., silicate-based bioceramics, can facilitate the healing of bone tissue. BG interacts with body fluids, forming a calcium-phosphate layer, crucial for implant integration. Polyvinyl alcohol (PVA)–chitosan (CS) blends are non-toxic, biodegradable, and biocompatible. PVA-CS was combined with BG for mechanical strengthening and to improve osteoblast cell activity. BG powders possess nanometric and open pores, as determined via transmission electron microscopy and a Brunauer–Emmett–Teller porosimetric analyzer. The ultimate tensile strength and elastic modulus of BG/PVA-CS films increased with the content of BG. PVA-CS films with 4% BG have an ultimate tensile strength of 1.13 ± 0.23 MPa, an improvement of 246% compared to PVA-CS films. The cell proliferation and alkaline phosphatase (ALP) activity of PVA-CS films were significantly increased after BG supplementation. In this study, a film with moderate tensile strength was pro-posed as a periodontal regeneration membrane that resists mechanical stress and facilitates the healing of bone tissue after periodontal regeneration surgery.