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<p>Porphyrin-mediated electrosyntheses of nanocomposites of gold nanoparticles (AuNPs) with tetraphenylporphyrin (TPP) or its complex with cobalt(II) (TPPCo(II)) in the absence and presence of the stabilizer poly(N-vinylpyrrolidone) (PVP) in dimethyl sulfoxide (DMSO) medium at room temperature were performed. The main goal of these experiments was to obtain nanocomposites having both catalytic activity and the ability to bind and deliver antitumor drugs. The syntheses results are solution-dispersed nanocomposites of mostly spherical AuNPs (Au/TPP, Au/TPP@PVP and Au/TPPCo(II)@PVP), stabilized by coordination interaction of pyrrolic porphyrin atoms with metal(0) in a porphyrin matrix formed by π-π stacking between porphyrin monomers. The powder X-ray diffraction (PXRD) data showed the presence of Au crystallites in obtained nanocomposites. The X-ray photoelectron spectroscopy (XPS) of obtained nanocomposite also confirms a presence of metallic gold and absence of gold oxidized form. The study of catalytic activity of the obtained nanocomposites in the test reaction of <i>p</i>-nitrophenol reduction by sodium borohydride has shown the presence of catalytic activity by all the studied composites, comparable and even prevailing in relation to the previously obtained results on the catalytic activity of AuNPs. The investigation of the ability to bind by the nanocomposites the antitumor drug doxorubicin (DOX) by fluorescence spectroscopy demonstrated the presence of varying degrees of DOX fluorescence quenching in the presence of composites: 16% (Au/TPP), 21% (Au/TPP@PVP) and 69% (Au/TPPCo(II)@PVP).</p>

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Mediated electrosynthesis of gold nanoparticles and porphyrins hybrid nanocomposites having catalytic activity and ability to bind antitumor drugs

  • 期刊论文

  • 发表日期：

    2025年4月27日

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  • Rezeda R. Fazleeva,
  • Gulnaz R. Nasretdinova,
  • Andrey A. Maslennikov,
  • Vladimir G. Evtyugin,
  • Igor V. Yanilkin,
  • Aidar T. Gubaidullin,
  • Albina Y. Ziganshina,
  • Vitaliy V. Yanilkin

摘要

Porphyrin-mediated electrosyntheses of nanocomposites of gold nanoparticles (AuNPs) with tetraphenylporphyrin (TPP) or its complex with cobalt(II) (TPPCo(II)) in the absence and presence of the stabilizer poly(N-vinylpyrrolidone) (PVP) in dimethyl sulfoxide (DMSO) medium at room temperature were performed. The main goal of these experiments was to obtain nanocomposites having both catalytic activity and the ability to bind and deliver antitumor drugs. The syntheses results are solution-dispersed nanocomposites of mostly spherical AuNPs (Au/TPP, Au/TPP@PVP and Au/TPPCo(II)@PVP), stabilized by coordination interaction of pyrrolic porphyrin atoms with metal(0) in a porphyrin matrix formed by π-π stacking between porphyrin monomers. The powder X-ray diffraction (PXRD) data showed the presence of Au crystallites in obtained nanocomposites. The X-ray photoelectron spectroscopy (XPS) of obtained nanocomposite also confirms a presence of metallic gold and absence of gold oxidized form. The study of catalytic activity of the obtained nanocomposites in the test reaction of p-nitrophenol reduction by sodium borohydride has shown the presence of catalytic activity by all the studied composites, comparable and even prevailing in relation to the previously obtained results on the catalytic activity of AuNPs. The investigation of the ability to bind by the nanocomposites the antitumor drug doxorubicin (DOX) by fluorescence spectroscopy demonstrated the presence of varying degrees of DOX fluorescence quenching in the presence of composites: 16% (Au/TPP), 21% (Au/TPP@PVP) and 69% (Au/TPPCo(II)@PVP).