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<p>This study presents an eco-friendly green reduction route under sunlight to prepare the bioactive silver nanoparticles (Ag NPs) using <i>Curcuma Caesia</i> rhizome essential oil (CCREO). Ag NPs are characterized through UV-visible (UV-Vis.), Fourier Transform Infrared (FTIR), and transmission electron microscopy (TEM) to confirm the formations of nanoparticles, surface morphology, and their chemical composition. Surface plasmon resonance band (SPR) observed at 439&#xa0;nm confirms the formation of Ag NPs with particle size ⁓ 6.88&#xa0;nm and different functional groups on their surface. It is observed that the phytochemicals present in the CCREO are responsible for the reduction and stabilization of Ag NPs as confirmed through FTIR analysis. Considering the biomedical potential of Ag NPs and the presence of carbonyl group on their surface, these NPs are further evaluated for anti-inflammatory and anti-cancerous applications. The in-vitro anti-inflammatory activity is done using the protein denaturation assay, and 32.22% inhibition at 12.5&#xa0;µg/mL and 81.64% at 200&#xa0;µg/mL is obtained. In-vivo anti-inflammatory activity conducted in wistar rats revealed that Ag NPs significantly lowered the edema caused by carrageenan injection within 72&#xa0;h. The results of anti-cancerous activity against MCF-7 cancer cell lines treated with high dose of Ag NPs (50&#xa0;µg/mL) showed a significant reduction of 32% against these cancer cells. It can be concluded that CCREO acts as a spectacular reducing and stabilizing agent for Ag NPs. The medicinal nature of the Ag NPs and functionalities present on their surface can be further explored for diverse biomedical applications.</p> Graphical abstract <p></p>

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Preparation of bioactive silver nanoparticles through green reduction with essential oil of Curcuma caesia under sunlight for anti-inflammatory and anticancerous applications

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Avinash Gangal,
  • Manisha Duseja,
  • Samta Manori,
  • Anita Bhatia,
  • Neeraj K. Sethiya,
  • Ravi K. Shukla

摘要

This study presents an eco-friendly green reduction route under sunlight to prepare the bioactive silver nanoparticles (Ag NPs) using Curcuma Caesia rhizome essential oil (CCREO). Ag NPs are characterized through UV-visible (UV-Vis.), Fourier Transform Infrared (FTIR), and transmission electron microscopy (TEM) to confirm the formations of nanoparticles, surface morphology, and their chemical composition. Surface plasmon resonance band (SPR) observed at 439 nm confirms the formation of Ag NPs with particle size ⁓ 6.88 nm and different functional groups on their surface. It is observed that the phytochemicals present in the CCREO are responsible for the reduction and stabilization of Ag NPs as confirmed through FTIR analysis. Considering the biomedical potential of Ag NPs and the presence of carbonyl group on their surface, these NPs are further evaluated for anti-inflammatory and anti-cancerous applications. The in-vitro anti-inflammatory activity is done using the protein denaturation assay, and 32.22% inhibition at 12.5 µg/mL and 81.64% at 200 µg/mL is obtained. In-vivo anti-inflammatory activity conducted in wistar rats revealed that Ag NPs significantly lowered the edema caused by carrageenan injection within 72 h. The results of anti-cancerous activity against MCF-7 cancer cell lines treated with high dose of Ag NPs (50 µg/mL) showed a significant reduction of 32% against these cancer cells. It can be concluded that CCREO acts as a spectacular reducing and stabilizing agent for Ag NPs. The medicinal nature of the Ag NPs and functionalities present on their surface can be further explored for diverse biomedical applications.

Graphical abstract