Scholarlink

<p>Tissue engineering holds promise in developing materials for biological applications, such as bone tissue repair. This study focuses on bioabsorbable and biocompatible polymers like Poly(L-lactic acid) (PLLA), Polyurethane (PU), and Polycaprolactone (PCL), along with nanohydroxyapatite (nHA), an essential osteoconductive ceramic. The main objective was the development and characterization of scaffolds obtained by Rotary Jet Spinning (RJS) using PLLA, PU, and PCL incorporated with nHA, for bone-related applications. The resulting scaffolds exhibited uniform fiber morphology and a rough surface, ideal for effective bone-tissue interaction. The crystallinity indicated the scaffolds’ bioactivity by apatite deposition in simulated body fluid. In addition, in vitro biological assays using preosteoblastic cells showed the biocompatibility of cells based on cell viability and adhesion parameters on the scaffolds. The results underscore the capacity of scaffolds incorporating nHA to promote both cell proliferation and osteoconduction, which are key elements essential for achieving effective bone regeneration.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Rotary Jet Spun Semicrystalline Polymers Containing Nanohydroxyapatite Increase Bioactivity and Cell Adhesion for Bone Applications

  • 期刊论文

  • 发表日期：

    2025年10月27日

查看全文
  • Isabella Caroline Pereira Rodrigues,
  • Jaiber Humberto Rodriguez Llanos,
  • Lúcia Helena Pereira Mendonça,
  • Karina Danielle Pereira,
  • Augusto Ducati Luchessi,
  • Éder Sócrates Najar Lopes,
  • Laís Pellizzer Gabriel

摘要

Tissue engineering holds promise in developing materials for biological applications, such as bone tissue repair. This study focuses on bioabsorbable and biocompatible polymers like Poly(L-lactic acid) (PLLA), Polyurethane (PU), and Polycaprolactone (PCL), along with nanohydroxyapatite (nHA), an essential osteoconductive ceramic. The main objective was the development and characterization of scaffolds obtained by Rotary Jet Spinning (RJS) using PLLA, PU, and PCL incorporated with nHA, for bone-related applications. The resulting scaffolds exhibited uniform fiber morphology and a rough surface, ideal for effective bone-tissue interaction. The crystallinity indicated the scaffolds’ bioactivity by apatite deposition in simulated body fluid. In addition, in vitro biological assays using preosteoblastic cells showed the biocompatibility of cells based on cell viability and adhesion parameters on the scaffolds. The results underscore the capacity of scaffolds incorporating nHA to promote both cell proliferation and osteoconduction, which are key elements essential for achieving effective bone regeneration.