<p><i>Ralstonia pseudosolanacearum</i> causes a lethal bacterial wilt disease in many plant species, posing significant economic challenges. Although tomato has been a primary model host for investigating the pathogenicity and systemic infection of this bacterium, this manuscript presents a comparative pathogenicity study between two closely related solanaceous hosts, tomato and eggplant, revealing differential host responses to the same pathogen, specifically through leaves and roots. Interestingly, eggplant seedlings exhibited a significantly higher susceptibility to cotyledon leaf inoculation than tomato seedlings. In the case of leaf inoculations, a few tomato seedlings escaping wilting (called escapees) were a usual observation at a high pathogen load (10⁹ CFU/mL); but in the case of eggplant seedlings, no escapees were observed even at a 100-fold lower pathogen concentration. The greater susceptibility of eggplant was further demonstrated by performing both single- and double-leaf inoculations in the seedlings. Surprisingly, root inoculations resulted in a significantly lower wilting for eggplant than for tomato seedlings. Interestingly, the escapees and wilted seedlings of tomato and eggplant were found to harbour <i>R. pseudosolanacearum</i> F1C1. The contrasting susceptibility between the two hosts regarding root and leaf regions indicates the tissue-dependent nature of susceptibility. The study underscores the value of employing multiple host species to uncover new insights into pathogen behaviour and host-pathogen interactions.</p>