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<p>Commercial airway stents often slip and deform, leading to severe complications such as mucosal injury, granulation tissue formation, and stent migration, which can cause recurrent airway obstruction and necessitate repeated interventions. Here, we introduce a 3D-printed tracheal stent composed of continuous bamboo fiber reinforced shape memory polylactic acid (BF/SMP). These naturally derived fibers (tensile strength ~ 1.90 GPa, modulus ~ 91.30 GPa) exhibit excellent mechanical resilience. Following an instantaneous thermal treatment, their interfacial compatibility with SMP is notably improved. The 30% BF/SMP stent can undergo over 1,000 three-point bending cycles under a 20&#xa0;N load, with a bending deflection of 30.85%. In vitro, it promotes bronchial epithelial cell proliferation. Preliminary animal studies suggest that the biomass-based stent provides airway support without causing significant inflammation or organ abnormalities. Overall, this work demonstrates a biomass-reinforced, thermally deployable airway stent concept and provides a foundation for future studies on catheter-compatible delivery and long-term in vivo performance.</p>

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3D-printed resilient biomass-based covered stents for tracheal implants

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月28日

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  • Tian Bai,
  • Xionghai Qin,
  • Zhenguo Wu,
  • Junjie Su,
  • Lin Li,
  • Hang Yao,
  • Zhaoxuan Niu,
  • Chengbin Yue,
  • Dong Wang,
  • Yiying Yue,
  • Wanli Cheng,
  • Chengjun Zeng,
  • Wei Zhao,
  • Guangping Han

摘要

Commercial airway stents often slip and deform, leading to severe complications such as mucosal injury, granulation tissue formation, and stent migration, which can cause recurrent airway obstruction and necessitate repeated interventions. Here, we introduce a 3D-printed tracheal stent composed of continuous bamboo fiber reinforced shape memory polylactic acid (BF/SMP). These naturally derived fibers (tensile strength ~ 1.90 GPa, modulus ~ 91.30 GPa) exhibit excellent mechanical resilience. Following an instantaneous thermal treatment, their interfacial compatibility with SMP is notably improved. The 30% BF/SMP stent can undergo over 1,000 three-point bending cycles under a 20 N load, with a bending deflection of 30.85%. In vitro, it promotes bronchial epithelial cell proliferation. Preliminary animal studies suggest that the biomass-based stent provides airway support without causing significant inflammation or organ abnormalities. Overall, this work demonstrates a biomass-reinforced, thermally deployable airway stent concept and provides a foundation for future studies on catheter-compatible delivery and long-term in vivo performance.