<p>Denture stomatitis (DS) is a significant health concern among denture wearers, caused by the overgrowth of <i>Candida albicans</i> and leading to inflammation beneath maxillary dentures. Current treatment options, including antifungal medications and denture disinfectants, are often limited by adverse effects and reduced efficacy. To address these challenges, this study aims to develop a novel dendritic polymer coating for dentures, which incorporates hydrophobic quaternary ammonium salts (QAS), hydrophilic catechol functional groups, and aggregation-induced emission (AIE) fluorophores. QAS, known for their broad-spectrum antimicrobial activity, are integrated into the coating to enhance the adhesion and antimicrobial properties. Catechol functional groups, rich in the dendritic polymer structure, contribute to improved stability and adhesion of the coating, which is crucial for long-term efficacy in the dynamic oral environment. Additionally, AIE fluorophores enable real-time monitoring of coating integrity, overcoming limitations of traditional fluorescent dyes. The study focuses on optimizing coating construction techniques, with an emphasis on enhancing adhesion, antimicrobial functionality, and real-time monitoring capabilities. Investigations into the antimicrobial mechanism of the coating aim to elucidate its potential in combating DS and offering solutions for therapeutic dentures. This approach presents a promising alternative to current treatments, addressing the urgent need for effective and durable antifungal therapies for denture-related stomatitis.</p> Graphical abstract <p></p>