<p>In order to promote efficient water management in the face of the ever-increasing needs of the population, the present study is a contribution to a better understanding of the groundwater resources of the Mayo-You watershed. A multidisciplinary approach combining remote sensing, geophysical survey, multi-criteria analysis, and geographic information systems was adopted to delineate groundwater favorability zones in the Mayo-You watershed. This is done in order to find suitable locations for the installation of new wells or boreholes in order to improve the population's water supply. The database used consists of satellite images, technical surveys of boreholes, topographic data, pedological data, and hydro-climatic data. Thirteen relevant criteria derived from this database were weighted and standardised following the method of the analytical hierarchy process. Three groundwater indicator maps of availability (potentiality), accessibility, and exploitability were created using a weighted overlay technique. These indicators are then considered as criteria for producing the groundwater favorability map. The final potential map was generated with excellent, good, moderate, and bad favorabilities with 11%, 36%, 13%, and 41% of the area, respectively. The results reveal that 47% of the Mayo You watershed is suitable for 74 new borehole sites, determined through the coincidence of good to excellent zones with the intersection of lineaments. Then, geophysical techniques involving electrical resistivity tomography (ERT) were used to provide a more detailed interpretation of the subsurface hydrogeological features. This technique has confirmed with accuracy the new borehole sites and also validated the favorability map. These results provide innovative scientific principles of groundwater resource exploration in the Mayo You area. Then, the findings will help the authorities of this area to plan better water management strategies and good sustainable groundwater extraction.</p>