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<p>Myocardial perfusion scintigraphy (MPS) is a technique that allows visualization of impaired blood supply to the myocardium. The method consists of administration of a radiopharmaceutical that accumulates in cardiomyocytes and reflects the function of mitochondria or transmembrane Na/K-pump. MPS is widely included in current clinical guidelines for the management of patients with coronary heart disease (Vrints in Eur Heart J 45(36):3415–3537, 2024). However, MPS limitations reduce its informative value and frequent result misinterpretations discredit the technique. The <i>“balanced ischaemia”</i> is one of these limitations, which is associated with a homogeneous decrease in perfusion of all coronary artery territories. The most common clinical scenario in which this phenomenon may occur is multivessel coronary artery disease. Based on the above, the question arises whether MPS needs to be provided for this group of patients with coronary artery diseases. We have tried to address this issue with the following clinical cases. These cases demonstrate the usefulness of MPS in patients with multivessel coronary artery disease, the importance of the information obtained for the treatment strategy, and the need for a comprehensive evaluation of the results of this technique.</p>

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Feasibility of gate myocardial perfusion scintigraphy in patients with multivessel coronary artery disease: clinical case

  • 期刊论文

  • 发表日期：

    2026年2月19日

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  • Andrew V. Mochula,
  • Arina A. Tsygikalo,
  • Yusufjon U. Alisherov,
  • Vasily V. Zatolokin,
  • Vladimir V. Shipulin,
  • Konstantin V. Zavadovsky

摘要

Myocardial perfusion scintigraphy (MPS) is a technique that allows visualization of impaired blood supply to the myocardium. The method consists of administration of a radiopharmaceutical that accumulates in cardiomyocytes and reflects the function of mitochondria or transmembrane Na/K-pump. MPS is widely included in current clinical guidelines for the management of patients with coronary heart disease (Vrints in Eur Heart J 45(36):3415–3537, 2024). However, MPS limitations reduce its informative value and frequent result misinterpretations discredit the technique. The “balanced ischaemia” is one of these limitations, which is associated with a homogeneous decrease in perfusion of all coronary artery territories. The most common clinical scenario in which this phenomenon may occur is multivessel coronary artery disease. Based on the above, the question arises whether MPS needs to be provided for this group of patients with coronary artery diseases. We have tried to address this issue with the following clinical cases. These cases demonstrate the usefulness of MPS in patients with multivessel coronary artery disease, the importance of the information obtained for the treatment strategy, and the need for a comprehensive evaluation of the results of this technique.