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Purpose <p>Kisspeptin stimulates gonadotropin-releasing hormone (GnRH) release and, by extension, gonadotropin secretion. Although continuous kisspeptin administration has been shown to dampen kisspeptin-induced GnRH release in non-human primates [<CitationRef CitationID="CR1">1</CitationRef>, <CitationRef CitationID="CR2">2</CitationRef>], this has not been replicated in the limited human studies reported to date. The objective of this study was to examine the effects of continuous kisspeptin administration on luteinizing hormone (LH) secretion in healthy men.</p> Methods <p>Three healthy adult men received a continuous intravenous infusion of kisspeptin-10 at a dose of 12.5 mcg/kg/h for 24&#xa0;h and underwent frequent blood sampling to characterize the effect on reproductive hormones.</p> Results <p>Continuous administration of kisspeptin resulted in an immediate increase in LH concentrations, from a baseline of 2.8–3.8 mIU/mL to the highest values of 17.5–30.6 mIU/mL (5- to eightfold above baseline), reached within 12–20&#xa0;h of infusion onset. LH concentrations subsequently declined by 13–47% from max to end of the infusion, settling at 10.7–22.8 mIU/mL. FSH and testosterone rose modestly in parallel.</p> Conclusion <p>While kisspeptin boluses have been employed to probe GnRH pulse generation, continuous infusion of kisspeptin is a complementary physiologic tool used to study dynamic changes in GnRH-induced LH secretion. Further studies are warranted to further elucidate the physiologic response of the kisspeptin receptor to non-pulsatile ligand administration.</p> Clinical trial registration <p>NCT01438073 (August 24, 2011).</p>

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Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月2日

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  • Amna Naveed,
  • Margaret F. Lippincott,
  • Maria Stamou,
  • Ravi Balasubramanian,
  • Nora K. Bryant,
  • Stephanie B. Seminara

摘要

Purpose

Kisspeptin stimulates gonadotropin-releasing hormone (GnRH) release and, by extension, gonadotropin secretion. Although continuous kisspeptin administration has been shown to dampen kisspeptin-induced GnRH release in non-human primates [1, 2], this has not been replicated in the limited human studies reported to date. The objective of this study was to examine the effects of continuous kisspeptin administration on luteinizing hormone (LH) secretion in healthy men.

Methods

Three healthy adult men received a continuous intravenous infusion of kisspeptin-10 at a dose of 12.5 mcg/kg/h for 24 h and underwent frequent blood sampling to characterize the effect on reproductive hormones.

Results

Continuous administration of kisspeptin resulted in an immediate increase in LH concentrations, from a baseline of 2.8–3.8 mIU/mL to the highest values of 17.5–30.6 mIU/mL (5- to eightfold above baseline), reached within 12–20 h of infusion onset. LH concentrations subsequently declined by 13–47% from max to end of the infusion, settling at 10.7–22.8 mIU/mL. FSH and testosterone rose modestly in parallel.

Conclusion

While kisspeptin boluses have been employed to probe GnRH pulse generation, continuous infusion of kisspeptin is a complementary physiologic tool used to study dynamic changes in GnRH-induced LH secretion. Further studies are warranted to further elucidate the physiologic response of the kisspeptin receptor to non-pulsatile ligand administration.

Clinical trial registration

NCT01438073 (August 24, 2011).