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Purpose <p>To examine the association between oral frailty and laboratory-based Frailty Index (FI-lab) in older adults.</p> Methods <p>This cross-sectional study included patients aged ≥ 65&#xa0;years who attended a frailty outpatient clinic. Oral frailty was assessed using the Oral Frailty five-item checklist. The FI-lab was constructed from 31 laboratory parameters, with frailty defined as an FI-lab value &gt; 0.21. The association between oral frailty and FI-lab–defined frailty was examined using multivariable logistic regression analysis.</p> Results <p>Among the 486 patients, the mean age was 77.9 ± 6.3&#xa0;years, and 63.6% were women. The prevalence of oral frailty was 49.6%, and the median FI-lab value was 0.16. Oral frailty was significantly associated with FI-lab-defined frailty after adjustment for age, sex, and comorbidities (odds ratio 1.52, 95% confidence interval 1.01–2.29).</p> Conclusion <p>Oral frailty is associated with FI-lab–defined frailty, suggesting a relationship between oral function and latent physiological vulnerability, as captured by the FI-lab.</p> Graphical abstract <p></p>

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Association between oral frailty and a laboratory-based frailty index in older adults

  • 期刊论文

  • 发表日期：

    2026年4月27日

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  • Shuzo Miyahara,
  • Keisuke Maeda,
  • Koki Kawamura,
  • Shosuke Satake,
  • Hiroyasu Akatsu,
  • Hidenori Arai

摘要

Purpose

To examine the association between oral frailty and laboratory-based Frailty Index (FI-lab) in older adults.

Methods

This cross-sectional study included patients aged ≥ 65 years who attended a frailty outpatient clinic. Oral frailty was assessed using the Oral Frailty five-item checklist. The FI-lab was constructed from 31 laboratory parameters, with frailty defined as an FI-lab value > 0.21. The association between oral frailty and FI-lab–defined frailty was examined using multivariable logistic regression analysis.

Results

Among the 486 patients, the mean age was 77.9 ± 6.3 years, and 63.6% were women. The prevalence of oral frailty was 49.6%, and the median FI-lab value was 0.16. Oral frailty was significantly associated with FI-lab-defined frailty after adjustment for age, sex, and comorbidities (odds ratio 1.52, 95% confidence interval 1.01–2.29).

Conclusion

Oral frailty is associated with FI-lab–defined frailty, suggesting a relationship between oral function and latent physiological vulnerability, as captured by the FI-lab.

Graphical abstract