<p>Satellite-retrieved methane (CH₄) concentration data offer a valuable opportunity for large-scale emissions monitoring. However, its widespread adoption remains challenging due to the data volume and varying data quality. A workflow to estimate the methane emission rate of major hydrocarbon plays based on the mass balance principle and using publicly available Sentinel-5P satellite data is presented. This workflow estimates the methane emission rate originating from specific regions. The proposed workflow is applied to estimate emissions from the Permian and Appalachian Basin regions in the United States. Our results show that the average methane emission rates from 2019 to 2021 are approximately 3.56 Mt/year for the Permian Basin and 4.46 Mt/year for the Appalachian Basin, decreasing in each of the 3&#xa0;years. The results are compared against volumes estimated by other means and reported in the literature. The proposed method is easy to implement and offers promising potential for practical and reliable estimates for long-term regional methane emission monitoring purposes for operators, governments, investors, and the general public.</p>