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<p>The simultaneous pancreas-kidney transplantation (SPK) is the gold standard for selected type 1 diabetes patients with terminal kidney failure. It combines the restoration of renal function with a permanent normoglycemia, which results in the long-term freedom of patients from dialysis and exogenous insulin treatment and a clear reduction in delayed cardiovascular and microangiopathic damage. Long-term data confirm a 1‑year patient survival of over 95% and a transplant survival of around 76% after 5 years. Despite this success the mean waiting time in Austria up to 2024 has more than doubled to 17.6 months, which is due to an aging donor pool and a declining surgical routine. These delays threaten the predialysis transplantation window and worsen the outcome of numerous patients.</p>

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Pankreastransplantation bei insulinpflichtigem Diabetes mellitus

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月12日

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  • Franka Messner-Rooprai,
  • Rupert Oberhuber

摘要

The simultaneous pancreas-kidney transplantation (SPK) is the gold standard for selected type 1 diabetes patients with terminal kidney failure. It combines the restoration of renal function with a permanent normoglycemia, which results in the long-term freedom of patients from dialysis and exogenous insulin treatment and a clear reduction in delayed cardiovascular and microangiopathic damage. Long-term data confirm a 1‑year patient survival of over 95% and a transplant survival of around 76% after 5 years. Despite this success the mean waiting time in Austria up to 2024 has more than doubled to 17.6 months, which is due to an aging donor pool and a declining surgical routine. These delays threaten the predialysis transplantation window and worsen the outcome of numerous patients.