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<p>Familial hypercholesterolemia is characterized by very high levels of low-density lipoprotein (LDL) cholesterol and is the most common monogenic disease. As a&#xa0;result, cardiovascular events can occur even at a&#xa0;young age. This is why early and consistent treatment is important. This can significantly reduce morbidity and mortality. The treatment is simple and several medications plus lipoprotein apheresis are available. Two medications are exclusively approved for homozygous familial hypercholesterolemia. Both finally enable effective treatment for those most severely affected, either in addition to or instead of apheresis.</p><p>Delaying treatment and not targeting specific goals has a&#xa0;negative impact on vascular health.</p><p>The ever-increasing amount of excellent data will hopefully lead to improvements in diagnosis and treatment, contributing to a&#xa0;longer, healthier life for this very high-risk group as well.</p>

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Familiäre Hypercholesterinämie – wann daran denken – wie vorgehen?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月24日

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  • Anja Vogt

摘要

Familial hypercholesterolemia is characterized by very high levels of low-density lipoprotein (LDL) cholesterol and is the most common monogenic disease. As a result, cardiovascular events can occur even at a young age. This is why early and consistent treatment is important. This can significantly reduce morbidity and mortality. The treatment is simple and several medications plus lipoprotein apheresis are available. Two medications are exclusively approved for homozygous familial hypercholesterolemia. Both finally enable effective treatment for those most severely affected, either in addition to or instead of apheresis.

Delaying treatment and not targeting specific goals has a negative impact on vascular health.

The ever-increasing amount of excellent data will hopefully lead to improvements in diagnosis and treatment, contributing to a longer, healthier life for this very high-risk group as well.