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<p>Stenosis development increases the risk of thrombosis and plaque vulnerability. Its progression and rupture potential depend strongly on blood flow. This study aims to examine the effect of blood flow on the power-law index and volume fraction in three types of stenosed arteries under the influence of a magnetic field. The blood flow is characterised using a non-Newtonian generalised power-law model. The Galerkin least-squares method is employed to solve the governing equations derived. The findings reveal distinct trends in velocity and wall shear stress in the post-stenotic regions for different generalised power-law indices and hybrid nanofluid volume fractions. The results indicate an inverse relationship between wall shear stress and nanoparticle volume fraction. As the volume fraction increases, wall shear stress decreases, suggesting that higher nanoparticle concentrations reduce the pressure drop in the artery. Applying a magnetic field results in an estimated 25% reduction in peak velocity and a 30% decrease in pressure drop across the three stenosis geometries. Increasing the hybrid nanoparticle volume fraction contributes a further 10–15% reduction in wall‑shear stress, while shifting from shear‑thinning to shear‑thickening behaviour enhances flow stability and lowers post‑stenotic recirculation by approximately 10%. This study contributes to the field of nanomedicine and targeted treatments, paving the way for personalised healthcare.</p>

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The impact of hybrid gold and silver nanoparticles on MHD GPL blood flow in an intricate arterial stenosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Kannigah Thirunanasambantham,
  • Zuhaila Ismail,
  • Yeou Jiann Lim,
  • Amnani Shamjuddin,
  • Prashanta Kumar Mandal

摘要

Stenosis development increases the risk of thrombosis and plaque vulnerability. Its progression and rupture potential depend strongly on blood flow. This study aims to examine the effect of blood flow on the power-law index and volume fraction in three types of stenosed arteries under the influence of a magnetic field. The blood flow is characterised using a non-Newtonian generalised power-law model. The Galerkin least-squares method is employed to solve the governing equations derived. The findings reveal distinct trends in velocity and wall shear stress in the post-stenotic regions for different generalised power-law indices and hybrid nanofluid volume fractions. The results indicate an inverse relationship between wall shear stress and nanoparticle volume fraction. As the volume fraction increases, wall shear stress decreases, suggesting that higher nanoparticle concentrations reduce the pressure drop in the artery. Applying a magnetic field results in an estimated 25% reduction in peak velocity and a 30% decrease in pressure drop across the three stenosis geometries. Increasing the hybrid nanoparticle volume fraction contributes a further 10–15% reduction in wall‑shear stress, while shifting from shear‑thinning to shear‑thickening behaviour enhances flow stability and lowers post‑stenotic recirculation by approximately 10%. This study contributes to the field of nanomedicine and targeted treatments, paving the way for personalised healthcare.