<p>An investigation into the utilization of egg shell powder (ESP) as a supplementary cementitious material in self-compacting concrete was conducted. The effects on rheological and mechanical properties were examined, and machine learning models were employed to predict mechanical properties of concrete. As the cement replacement level with ESP increased from 0 to 16%, a slight decrease in slump flow was observed, while moderate increases in T50 and V-funnel times were noted. All mixes were found to meet the workability requirements for self-compacting concrete. Compressive strength was observed to increase with ESP content up to 16%, achieving comparable results to the control mix at 28&#xa0;days. Five machine learning models were evaluated for mechanical properties of concrete prediction, with the multi-layer perceptron model demonstrating the highest accuracy in all the properties. These results indicate that egg shell powder can be efficaciously utilized as a supplementary cementitious material in self-compacting concrete, potentially up to 16% replacement, without significant compromise to workability or compressive strength. This study contributes to sustainable construction practices by demonstrating the viability of egg shell powder as a supplementary cementitious material potentially mitigating the environmental impact of concrete production.</p>