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<p>To evaluate the short-term systemic inflammatory response induced by non-surgical periodontal treatment (NSPT) by analyzing cardiovascular and inflammatory biomarkers. Thirty-four systemically healthy patients with periodontitis were randomly assigned to quadrant debridement (QD) or full-mouth debridement (FMD). Serum samples were collected at baseline, 24&#xa0;h, and 48&#xa0;h after NSPT to measure Copeptin (COP), B-type Natriuretic Peptide (BNP), N-terminal pro-BNP (NT-proBNP), Interleukin-6 (IL-6), and Tumor Necrosis Factor-alpha (TNF-α). Periodontal parameters were assessed at baseline and 45 days. Significant clinical improvement was observed in both groups at 45 days (<i>p</i> &lt; 0.05). COP levels did not significantly vary over time (<i>p</i> &gt; 0.05). BNP showed a numerical reduction at 24 and 48&#xa0;h in the FMD group, but the difference was not statistically significant (<i>p</i> &gt; 0.05). NT-proBNP levels did not change over time within either group (<i>p</i> &gt; 0.05), although significant intergroup differences were observed at all time points (<i>p</i> &lt; 0.05). IL-6 increased at 48&#xa0;h in the QD group (<i>p</i> &lt; 0.05), and TNF-α increased at 24&#xa0;h in the same group (<i>p</i> &lt; 0.05), with no significant intergroup differences over time (<i>p</i> &gt; 0.05). NT-proBNP showed a moderate positive correlation with TNF-α (QD <i>p</i> = 0.026; FMD <i>p</i> = 0.03; total sample <i>p</i> = 0.002) and with IL-6 in the FMD group (<i>p</i> = 0.002). NSPT induced a transient increase in inflammatory cytokines but did not significantly increase cardiovascular risk biomarkers within 48&#xa0;h in systemically healthy individuals. Brazilian Registry of Clinical Trials (ReBEC), RBR-66tr7h.</p>

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Short-term cardiovascular risk biomarkers in acute phase response after nonsurgical periodontal therapy

  • 期刊论文

  • 发表日期：

    2026年5月6日

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  • Catarina Martins Tahim,
  • Karine Figueredo da Costa,
  • Milla Sprone Tavares,
  • Osmaria Letthycia Carvalho Leal,
  • Flávia Aparecida Chaves Furlaneto Messora,
  • Mário Taba Jr.

摘要

To evaluate the short-term systemic inflammatory response induced by non-surgical periodontal treatment (NSPT) by analyzing cardiovascular and inflammatory biomarkers. Thirty-four systemically healthy patients with periodontitis were randomly assigned to quadrant debridement (QD) or full-mouth debridement (FMD). Serum samples were collected at baseline, 24 h, and 48 h after NSPT to measure Copeptin (COP), B-type Natriuretic Peptide (BNP), N-terminal pro-BNP (NT-proBNP), Interleukin-6 (IL-6), and Tumor Necrosis Factor-alpha (TNF-α). Periodontal parameters were assessed at baseline and 45 days. Significant clinical improvement was observed in both groups at 45 days (p < 0.05). COP levels did not significantly vary over time (p > 0.05). BNP showed a numerical reduction at 24 and 48 h in the FMD group, but the difference was not statistically significant (p > 0.05). NT-proBNP levels did not change over time within either group (p > 0.05), although significant intergroup differences were observed at all time points (p < 0.05). IL-6 increased at 48 h in the QD group (p < 0.05), and TNF-α increased at 24 h in the same group (p < 0.05), with no significant intergroup differences over time (p > 0.05). NT-proBNP showed a moderate positive correlation with TNF-α (QD p = 0.026; FMD p = 0.03; total sample p = 0.002) and with IL-6 in the FMD group (p = 0.002). NSPT induced a transient increase in inflammatory cytokines but did not significantly increase cardiovascular risk biomarkers within 48 h in systemically healthy individuals. Brazilian Registry of Clinical Trials (ReBEC), RBR-66tr7h.