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<p>This systematic review aimed to provide an overview of the role of gingival fibroblasts in the pathogenesis of periodontitis according to in vitro studies. A comprehensive search was conducted across the following electronic databases: PubMed, Latin American and Caribbean Health Sciences Literature (LILACS), EMBASE, and the Brazilian Bibliography of Dentistry. These databases were accessed through the Virtual Health Library (VHL), Scientific Electronic Library Online (SciELO), Cochrane Library, and SCOPUS. No year or language restrictions were applied. The descriptors used were: “fibroblasts”, “biofilm”, “periodontitis”, and “inflammatory response”, using “AND” to combine of fibroblasts and periodontitis with biofilm or inflammatory response. From a total of 2.956 titles, 13 articles were included in this systematic review. Risk of bias was assessed using the QUIN tool. All studies presented medium risk of bias. The biofilm challenge was performed either in vivo or in vitro conditions. The expression of more than 15 inflammatory mediators was evaluated. Interleukin 6, IL-1β and Prostaglandin E2 were the most frequently evaluated cytokines followed by IL-8, COX-2, RANK/RANKL, CSF 1 and IL-34 and their expression increased significantly in response to a biofilm challenge either in patients with periodontitis or after exposure to in vitro biofilm models. Moderate evidence, derived from medium-risk studies, supports the involvement of gingival fibroblasts in the periodontal inflammation, as demonstrated by the increased expression of several pro-inflammatory cytokines following challenge with pathogenic biofilms.</p>

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The role of gingival fibroblast in the immune periodontal response: a systematic review of in vitro studies

  • 期刊论文

  • 发表日期：

    2026年3月2日

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  • Camila Akemi Izumi,
  • Reila Taina Mendes,
  • Geisla Mary Silva Soares

摘要

This systematic review aimed to provide an overview of the role of gingival fibroblasts in the pathogenesis of periodontitis according to in vitro studies. A comprehensive search was conducted across the following electronic databases: PubMed, Latin American and Caribbean Health Sciences Literature (LILACS), EMBASE, and the Brazilian Bibliography of Dentistry. These databases were accessed through the Virtual Health Library (VHL), Scientific Electronic Library Online (SciELO), Cochrane Library, and SCOPUS. No year or language restrictions were applied. The descriptors used were: “fibroblasts”, “biofilm”, “periodontitis”, and “inflammatory response”, using “AND” to combine of fibroblasts and periodontitis with biofilm or inflammatory response. From a total of 2.956 titles, 13 articles were included in this systematic review. Risk of bias was assessed using the QUIN tool. All studies presented medium risk of bias. The biofilm challenge was performed either in vivo or in vitro conditions. The expression of more than 15 inflammatory mediators was evaluated. Interleukin 6, IL-1β and Prostaglandin E2 were the most frequently evaluated cytokines followed by IL-8, COX-2, RANK/RANKL, CSF 1 and IL-34 and their expression increased significantly in response to a biofilm challenge either in patients with periodontitis or after exposure to in vitro biofilm models. Moderate evidence, derived from medium-risk studies, supports the involvement of gingival fibroblasts in the periodontal inflammation, as demonstrated by the increased expression of several pro-inflammatory cytokines following challenge with pathogenic biofilms.