Scholarlink

<p>Exposure to particulate matter (PM) and its adverse health effects are linked to oxidative stress processes. The oxidative potential (OP) serves as a valuable exposure metric for a more nuanced understanding of health responses to PM. This study investigates the OP of PM<sub>2.5</sub> and PM<sub>1</sub> and the respiratory deposition doses of PM across various settings- urban, roadside, and rural in Agra, India. The Multiple Path Dosimetry model (MPPD) was used to assess respiratory deposition doses in four different subject categories: infants, children, adults, and retirees. The study findings reveal that the OP of PM varies considerably throughout Agra, OP- DTTv (352.8 ± 95.65 pmol/min/m³) values for PM<sub>2.5</sub> significantly higher than OP-DTTv (266 ± 79.86 pmol/min/m<sup>3</sup>) for PM<sub>1</sub>. On the other hand, OP-DTTm values for PM<sub>1</sub> (15.22 ± 8.73 pmol/min/µg) were elevated than PM<sub>2.5</sub> (10.29 ± 7 pmol/min/µg) indicating increased PM<sub>1</sub> levels in roadside settings. The study findings reveal that the OP of PM varies considerably throughout Agra, with OP-DTTv values for PM<sub>2.5</sub> were significantly higher and OP-DTTm values indicating increased PM<sub>1</sub> levels in roadside settings. Notably, the highest deposition values of PM<sub>2.5</sub> were found in the upper respiratory tract, particularly in the head regions (47%) conversely, the pulmonary region’s (73%) and tracheobronchial region (17%) deposition was predominantly associated with PM<sub>1</sub>. Children and retirees exhibited the highest deposition mass per unit area, with the elderly being particularly vulnerable. In instances of lobar depositions, lower lobes experience the maximum deposition (65%) compare to the upper (27%) and middle lobes (8%) and patterns indicated increased risk for children and infants. Lobar analyses confirm deeper PM<sub>1</sub> penetration, amplifying pulmonary threats. Retirees had higher inhalation doses in the head region, and children experienced doses mainly in the tracheobronchial and pulmonary regions. Health risk assessments highlighted that children faced greater risks compared to infants, adults, and retirees at all locations, underscoring an urgent need to mitigate particulate pollution.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Respiratory Deposition of Particulate Matter Associated Oxidative Potential in Agra: A Dosimetric Assessment Using MPPD Model

  • 期刊论文

  • 发表日期：

    2026年5月25日

查看全文
  • Tulika Tripathi,
  • Ajay Taneja

摘要

Exposure to particulate matter (PM) and its adverse health effects are linked to oxidative stress processes. The oxidative potential (OP) serves as a valuable exposure metric for a more nuanced understanding of health responses to PM. This study investigates the OP of PM2.5 and PM1 and the respiratory deposition doses of PM across various settings- urban, roadside, and rural in Agra, India. The Multiple Path Dosimetry model (MPPD) was used to assess respiratory deposition doses in four different subject categories: infants, children, adults, and retirees. The study findings reveal that the OP of PM varies considerably throughout Agra, OP- DTTv (352.8 ± 95.65 pmol/min/m³) values for PM2.5 significantly higher than OP-DTTv (266 ± 79.86 pmol/min/m3) for PM1. On the other hand, OP-DTTm values for PM1 (15.22 ± 8.73 pmol/min/µg) were elevated than PM2.5 (10.29 ± 7 pmol/min/µg) indicating increased PM1 levels in roadside settings. The study findings reveal that the OP of PM varies considerably throughout Agra, with OP-DTTv values for PM2.5 were significantly higher and OP-DTTm values indicating increased PM1 levels in roadside settings. Notably, the highest deposition values of PM2.5 were found in the upper respiratory tract, particularly in the head regions (47%) conversely, the pulmonary region’s (73%) and tracheobronchial region (17%) deposition was predominantly associated with PM1. Children and retirees exhibited the highest deposition mass per unit area, with the elderly being particularly vulnerable. In instances of lobar depositions, lower lobes experience the maximum deposition (65%) compare to the upper (27%) and middle lobes (8%) and patterns indicated increased risk for children and infants. Lobar analyses confirm deeper PM1 penetration, amplifying pulmonary threats. Retirees had higher inhalation doses in the head region, and children experienced doses mainly in the tracheobronchial and pulmonary regions. Health risk assessments highlighted that children faced greater risks compared to infants, adults, and retirees at all locations, underscoring an urgent need to mitigate particulate pollution.

Graphical Abstract