Scholarlink

<p>This study focuses on the development of silver (Ag) and zinc (Zn) co-doped hydroxyapatite (HAP) coatings deposited on Ti-6Al-4&#xa0;V substrates using a sol-gel technique to enhance the performance of orthopedic implants. XRD and FTIR analyses confirmed that the hexagonal HAP structure was maintained, indicating the successful incorporation of Ag<sup>+</sup> and Zn<sup>2+</sup> ions without inducing secondary phases. FESEM and EDX characterization revealed a composition-dependent surface morphology, with the Ag/Zn coatings exhibiting an improved, uniform, and pore-free surface. The 3Ag/4Zn coating demonstrated superior adhesion strength (43.18 ± 1.17&#xa0;MPa), retaining ~ 92% of its integrity after 12 days in simulated body fluid (SBF). Electrochemical impedance spectroscopy (EIS) identified this composition as having the highest charge-transfer resistance (3.17 MΩ × cm<sup>2</sup>), underscoring its exceptional enhanced corrosion resistance and barrier stability. XPS spectra further verified the successful incorporation of Ag<sup>+</sup> and Zn<sup>2+</sup> into the HAP lattice and the presence of hydroxylated surface groups favorable for cell attachment. In vitro biological assessments with MG-63 osteoblast-like cells showed excellent in vitro cytocompatibility and enhanced cell viability (113% after 72&#xa0;h) for the 3Ag/4Zn coating, attributed to the combined effect of the dopant ions. These results collectively introduce Ag/Zn co-doping, particularly the 3Ag/4Zn formulation, as a highly promising strategy for creating multifunctional, load-bearing implants with improved structural, electrochemical, and biological properties.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Concurrent enhancement of structural, electrochemical, and biological performance in Ag/Zn co-doped hydroxyapatite coatings on Ti-6Al-4 V prepared via sol–gel method

  • 期刊论文

  • 发表日期：

    2026年3月9日

查看全文
  • Qamar Abuhassan,
  • Ahmed Aldulaimi,
  • Omayma Salim Waleed,
  • G. PadmaPriya,
  • S. Supriya,
  • Subhashree Ray,
  • Renu Sharma,
  • Saodatkhon Ibragimova,
  • Z. Saripova,
  • Doniyor Jumanazarov,
  • ‎Aseel Smerat‎

摘要

This study focuses on the development of silver (Ag) and zinc (Zn) co-doped hydroxyapatite (HAP) coatings deposited on Ti-6Al-4 V substrates using a sol-gel technique to enhance the performance of orthopedic implants. XRD and FTIR analyses confirmed that the hexagonal HAP structure was maintained, indicating the successful incorporation of Ag+ and Zn2+ ions without inducing secondary phases. FESEM and EDX characterization revealed a composition-dependent surface morphology, with the Ag/Zn coatings exhibiting an improved, uniform, and pore-free surface. The 3Ag/4Zn coating demonstrated superior adhesion strength (43.18 ± 1.17 MPa), retaining ~ 92% of its integrity after 12 days in simulated body fluid (SBF). Electrochemical impedance spectroscopy (EIS) identified this composition as having the highest charge-transfer resistance (3.17 MΩ × cm2), underscoring its exceptional enhanced corrosion resistance and barrier stability. XPS spectra further verified the successful incorporation of Ag+ and Zn2+ into the HAP lattice and the presence of hydroxylated surface groups favorable for cell attachment. In vitro biological assessments with MG-63 osteoblast-like cells showed excellent in vitro cytocompatibility and enhanced cell viability (113% after 72 h) for the 3Ag/4Zn coating, attributed to the combined effect of the dopant ions. These results collectively introduce Ag/Zn co-doping, particularly the 3Ag/4Zn formulation, as a highly promising strategy for creating multifunctional, load-bearing implants with improved structural, electrochemical, and biological properties.