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<p>As society ages, the treatment of osteoporosis has become an issue that must be solved. In this study, we evaluated the effects of hydroxyapatite, βTCP, strontium calcium-deficient apatite, and strontium βTCP on osteoclasts using osteoporosis model zebrafish. Calcium-deficient strontium nanocrystalline apatite was achieved by mechanochemical synthesis. Characterization of the synthesized samples was analyzed by XRD, FTIR, and TG/DTA. In an experiment where zebrafish, used as a model for osteoporosis, were exposed to various apatites, the morphology of osteoclasts was observed by evaluating their scales. The apatites to which the zebrafish were exposed were suggested to influence the differentiation of osteoclasts.</p> Graphical Abstract <p></p>

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Mechanochemical synthesis of strontium-containing calcium-deficient apatite and its effect on osteoclasts: in vivo study using zebrafish

  • 期刊论文

  • 发表日期：

    2026年1月3日

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  • Yuta Otsuka,
  • Liqing Zang,
  • Yasuhito Shimada,
  • Hiroshi Kono,
  • Masafumi Kikuchi

摘要

As society ages, the treatment of osteoporosis has become an issue that must be solved. In this study, we evaluated the effects of hydroxyapatite, βTCP, strontium calcium-deficient apatite, and strontium βTCP on osteoclasts using osteoporosis model zebrafish. Calcium-deficient strontium nanocrystalline apatite was achieved by mechanochemical synthesis. Characterization of the synthesized samples was analyzed by XRD, FTIR, and TG/DTA. In an experiment where zebrafish, used as a model for osteoporosis, were exposed to various apatites, the morphology of osteoclasts was observed by evaluating their scales. The apatites to which the zebrafish were exposed were suggested to influence the differentiation of osteoclasts.

Graphical Abstract