<p>Groundwater is an indispensable resource for human survival, though its quantity and quality vary spatially. Climate change and human activities are currently placing enormous pressure on countless aquifers, leading to significant problems of overexploitation and contamination. The objective of the study was to prioritize Mexican aquifers, with particular attention to water quantity. This was achieved using the Analytic Hierarchy Process within a Geographic Information System framework, analyzing socioeconomic and hydrogeological criteria, as well as climate change scenarios. These included a climate change indicator for the SSP2-4.5 and SSP5-8.5 scenarios, five socioeconomic indicators (water dependence, public, agricultural, and industrial use, and total population), and three hydrogeological indicators (water availability, total withdrawal over total recharge, and renewable water resources per capita). The indicators were based on official groundwater data from the year 2020. The most significant finding was a country-level map prioritizing aquifer. In the SSP2-4.5 scenario, 111 aquifers were classified in the “very high priority” category, a number which increased to 136 under the SSP5-8.5 scenario. Notably, 70 of these prioritized aquifers are already in a state of overexploitation.</p> Graphical Abstract <p></p>