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<p>Bimetallic zinc/nickel metal-organic frameworks (Zn/Ni-MOFs) incorporating terephthalic acid (Zn/Ni-TPA) and trimesic acid (Zn/Ni-TA) as the organic linkers hydrothermally synthesized and evaluated for drug delivery, catalytic reduction and cytotoxicity applications. Structural and physicochemical characterization confirmed nanocrystalline frameworks with crystallite sizes of 16–17&#xa0;nm and hydrodynamic diameters of 264–284&#xa0;nm with negative zeta potentials affirming colloidal stability. Notably, both MOFs demonstrated high acetaminophen loading efficiencies (80.50% and 87.87%) and pH-responsive release (85.01% and 89.75% at pH 5.0 within 48&#xa0;h), suggesting the suitability for targeted, microenvironment-triggered delivery. The frameworks also exhibited an exceptional catalytic performance in the reduction of 4-nitroaniline, achieving near-complete conversion (98.99% and 99.21%) within 2–3&#xa0;min. The cytotoxicity testing against HeLa cells revealed biocompatibility &lt; 25&#xa0;µg/mL, indicating safe therapeutic application. Hence the findings established that Zn/Ni bimetallic MOFs as multifunctional nanomaterials with prospective dual applications in controlled medication release and environmental catalysis.</p>

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Nanoarchitectonics of Functionalized Nano Zn/Ni-MOF for Effective pH Controlled Drug Delivery, Nitroaromatic Catalytic Reduction and Cytotoxicity Analysis

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • C. Senthamil,
  • J. Hemalatha,
  • J. J. Umashankar,
  • K. Preethi,
  • I. Prabha

摘要

Bimetallic zinc/nickel metal-organic frameworks (Zn/Ni-MOFs) incorporating terephthalic acid (Zn/Ni-TPA) and trimesic acid (Zn/Ni-TA) as the organic linkers hydrothermally synthesized and evaluated for drug delivery, catalytic reduction and cytotoxicity applications. Structural and physicochemical characterization confirmed nanocrystalline frameworks with crystallite sizes of 16–17 nm and hydrodynamic diameters of 264–284 nm with negative zeta potentials affirming colloidal stability. Notably, both MOFs demonstrated high acetaminophen loading efficiencies (80.50% and 87.87%) and pH-responsive release (85.01% and 89.75% at pH 5.0 within 48 h), suggesting the suitability for targeted, microenvironment-triggered delivery. The frameworks also exhibited an exceptional catalytic performance in the reduction of 4-nitroaniline, achieving near-complete conversion (98.99% and 99.21%) within 2–3 min. The cytotoxicity testing against HeLa cells revealed biocompatibility < 25 µg/mL, indicating safe therapeutic application. Hence the findings established that Zn/Ni bimetallic MOFs as multifunctional nanomaterials with prospective dual applications in controlled medication release and environmental catalysis.