<p>Urban morphology significantly impacts outdoor urban ventilation and wind conditions, affecting human health, comfort, and the energy requirements for building cooling and ventilation. The layout and height of buildings can alter a neighborhood's wind patterns and air quality. Although studies on urban ventilation have been conducted in various cities, this issue has not been sufficiently explored concerning Tehran's commonly occurring building layouts. By integrating advanced indoor ventilation metrics into the analysis of outdoor airflow, this study addresses a critical research gap in regional urban ventilation and provides a replicable framework for similar cities. It investigates four prevalent building layouts in Tehran, analyzing their effects on air patterns, velocity ratios, air delay, and wake behavior at three different heights under two wind directions. Three-dimensional steady-state RANS simulations employing the standard k-epsilon model were conducted to assess the impact of urban design on airflow. CFD simulations were validated using ANSYS Fluent by comparing them with results obtained from wind tunnel tests. The results show that the parallel block layout in Case 3 reduces the maximum air delay by 34% compared to other cases. Additionally, the parallel layouts exhibit a higher velocity ratio and lower building impact at the pedestrian level. A 45° wind direction increases the velocity ratio by approximately 66% compared to a 0° wind flow. Conversely, the central courtyard structure and converging layout result in more critical wind conditions. These findings can be invaluable for architects and urban designers, especially during the design phase.</p>