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<p>Intelligent multi-mode chromatographic stationary phases represent a critical pathway for overcoming the analytical challenges posed by complex samples. Herein, we report a novel chromatographic stationary phase, Sil@DNR hydrogel, based on an interfacial dynamics-induced network reorganization (DNR) strategy with integrated temperature-responsive characteristics. DNR strategy employs a one-pot method in which silica is functionalized with dimethyl dimethoxy silicane (DMDMS) while concurrently being coated with a copolymer hydrogel network of polyacrylamide (PAAM) and poly(N-isopropylacrylamide) (PNIPAM). During separation, the DNR strategy promotes the formation and uniform distribution of hydrophobic domains, while the inherent high water-absorption capacity of the hydrogel provides strong hydrophilic interactions. Sil@DNR hydrogel enables the simultaneous and efficient separation of both hydrophilic interaction liquid chromatography (HILIC) and reversed-phase liquid chromatography (RPLC), effectively addressing the inherent imbalance between hydrophilic and hydrophobic separation capabilities observed in traditional multi-mode chromatographic materials. Notably, the DNR strategy enables the Sil@DNR hydrogel to separate hydroxybenzoic acid isomers, while the PNIPAM imparts pronounced temperature-responsive characteristics to the material, permitting the dynamic and reversible regulation of separation selectivity through adjustments in column temperature.</p>

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Temperature-Responsive DNR Hydrogel Coating Silica Used for Multi-Mode Chromatographic Stationary Phase

  • 期刊论文

  • 发表日期：

    2026年7月31日

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  • Shuning Li,
  • Xiaojing Liang,
  • Shuai Wang,
  • Xiaofeng Lu,
  • Licheng Wang

摘要

Intelligent multi-mode chromatographic stationary phases represent a critical pathway for overcoming the analytical challenges posed by complex samples. Herein, we report a novel chromatographic stationary phase, Sil@DNR hydrogel, based on an interfacial dynamics-induced network reorganization (DNR) strategy with integrated temperature-responsive characteristics. DNR strategy employs a one-pot method in which silica is functionalized with dimethyl dimethoxy silicane (DMDMS) while concurrently being coated with a copolymer hydrogel network of polyacrylamide (PAAM) and poly(N-isopropylacrylamide) (PNIPAM). During separation, the DNR strategy promotes the formation and uniform distribution of hydrophobic domains, while the inherent high water-absorption capacity of the hydrogel provides strong hydrophilic interactions. Sil@DNR hydrogel enables the simultaneous and efficient separation of both hydrophilic interaction liquid chromatography (HILIC) and reversed-phase liquid chromatography (RPLC), effectively addressing the inherent imbalance between hydrophilic and hydrophobic separation capabilities observed in traditional multi-mode chromatographic materials. Notably, the DNR strategy enables the Sil@DNR hydrogel to separate hydroxybenzoic acid isomers, while the PNIPAM imparts pronounced temperature-responsive characteristics to the material, permitting the dynamic and reversible regulation of separation selectivity through adjustments in column temperature.