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<p>Wound infection poses a significant global health challenge, where real-time monitoring constitutes a critical determinant in the diagnosis and treatment of wounds. While traditional detection methods exhibit inherent limitations, biosensing technology offers a convenient and rapid solution that can be applied across various scenarios, enabling portability, and rapid response monitoring of wound infections. This review focuses on the cutting-edge developments in biosensor applications for real-time monitoring of wound infection, with particular emphasis on biomarker detection strategies. Firstly, single-factor biosensing platforms for real-time wound infection monitoring were discussed through the comparative analysis of colorimetric, fluorescence, and electrochemical transduction mechanisms. Secondly, the technological evolutions toward multi-channel wound infection monitoring approaches were introduced, incorporating mechanism analysis and sensing applications. Then the selection of wound infection markers, and single-factor and multi-factor detection approaches were reviewed, providing reasonable strategies for real-time monitoring of infected wound healing at different stages.</p>

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Real-time Monitoring of Wound Infection Based on Multi-channel Biomedical Sensors

  • 期刊论文

  • 发表日期：

    2025年11月6日

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  • Bin Fan,
  • Shaopeng Wang,
  • Songsong Huang,
  • Shuai Ma,
  • Huachu Zuo,
  • Shuang Li,
  • Zetao Chen

摘要

Wound infection poses a significant global health challenge, where real-time monitoring constitutes a critical determinant in the diagnosis and treatment of wounds. While traditional detection methods exhibit inherent limitations, biosensing technology offers a convenient and rapid solution that can be applied across various scenarios, enabling portability, and rapid response monitoring of wound infections. This review focuses on the cutting-edge developments in biosensor applications for real-time monitoring of wound infection, with particular emphasis on biomarker detection strategies. Firstly, single-factor biosensing platforms for real-time wound infection monitoring were discussed through the comparative analysis of colorimetric, fluorescence, and electrochemical transduction mechanisms. Secondly, the technological evolutions toward multi-channel wound infection monitoring approaches were introduced, incorporating mechanism analysis and sensing applications. Then the selection of wound infection markers, and single-factor and multi-factor detection approaches were reviewed, providing reasonable strategies for real-time monitoring of infected wound healing at different stages.