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<p>In this study, a novel colorimetric detection method for tryptophan is developed using Au@MnO<sub>2</sub> NPs based on their redox reaction. Tryptophan etches the outer MnO<sub>2</sub> NPs shell and forms a stable protective layer outside the released Au NPs core in situ, accompanied by a noticeable color change from brown to pink. According to the absorbance ratio of 545&#xa0;nm and 580&#xa0;nm (<i>A</i><sub>545</sub>/<i>A</i><sub>580</sub>), a rapid (within 1&#xa0;min), accurate, and specific detection method for tryptophan is constructed amidst other common amino acids. Coupling with a smartphone application, integrated Au@MnO<sub>2</sub> NPs-based portable test strips can be used for the point-of-care testing (POCT) of tryptophan.</p>

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Point-of-Care Testing for Abnormal Amino Acid Metabolism: Visualized Colorimetric Detection of Tryptophan Based on Au@MnO2 Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年6月12日

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  • Yi Huang,
  • Xiaoting Zhuang,
  • Ruyi Zhang,
  • Qinghui Yu,
  • Ziwei Kuang,
  • Chubei Qiu,
  • Zhaofan Luo,
  • Mingcong Rong,
  • Changqing Yi

摘要

In this study, a novel colorimetric detection method for tryptophan is developed using Au@MnO2 NPs based on their redox reaction. Tryptophan etches the outer MnO2 NPs shell and forms a stable protective layer outside the released Au NPs core in situ, accompanied by a noticeable color change from brown to pink. According to the absorbance ratio of 545 nm and 580 nm (A545/A580), a rapid (within 1 min), accurate, and specific detection method for tryptophan is constructed amidst other common amino acids. Coupling with a smartphone application, integrated Au@MnO2 NPs-based portable test strips can be used for the point-of-care testing (POCT) of tryptophan.