<p>This article explores the communication challenges faced by health professionals working with patients from high-context cultures (i.e. those that emphasize non-verbal communication), particularly in Southeast Asia, and proposes strategies to enhance interaction and patient care. Attention should be put on the impact of cultural dimensions such as high power distance and collectivism on patient behaviour and decision-making. In high power distance cultures, patients may be passive and reluctant to voice concerns, while collectivistic values often influence decisions through family or community input. To address these challenges, communication guides designed to improve interactions include observing subtle non-verbal and para-verbal cues, practicing active listening, encouraging patient participation, providing adequate consultation time, and discussing care plans collaboratively. Additionally, using familial terms of address and incorporating Kleinmann’s eight questions are recommended to bridge cultural gaps and facilitate a better understanding of patients’ perspectives. The proposed strategies aim to foster a culturally sensitive and patient-centred approach, enhancing communication, improving patient satisfaction, and leading to better health outcomes. By implementing these practices, health professionals can navigate cultural complexities more effectively and deliver high-quality, respectful care.</p>