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<b>Purpose:</b> <p>Most preclinical positron emission tomography (PET) systems are designed for small-animal imaging and offer a limited axial field of view (FOV). The step-and-shoot (S&amp;S) acquisition mode is employed for whole-body imaging of larger animals. However, the reduced axial sensitivity at the edges of the FOV may lead to increased noise at the image boundaries. Continuous bed motion (CBM) acquisition mode is an efficient whole-body imaging protocol available on some clinical PET systems. This study aims to evaluate and implement the CBM acquisition mode on the preclinical digital PET/CT system RAYCAN Discoverist 180 (D180) and to compare its performance with the S&amp;S mode.</p> <b>Methods:</b> <p>The CBM acquisition mode enables imaging by mapping the normalized events into the virtual system, followed by random and attenuation correction. In addition, the effects of different virtual crystal sizes on image quality were evaluated. The mode was first validated via Monte Carlo simulations and subsequently implemented in the D180 system for real imaging.</p> <b>Results:</b> <p>In contrast with the S&amp;S acquisition mode, the CBM acquisition mode demonstrates more consistent axial noise levels. Adjusting the virtual crystal size can improve the axial spatial resolution in CBM acquisition mode while maintaining its benefit in axial noise uniformity.</p> <b>Conclusion:</b> <p>The CBM acquisition mode reduces scanning complexity and maintains axial noise uniformity, making it an attractive alternative to the S&amp;S acquisition mode for imaging larger animals in preclinical PET systems.</p>

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Implementation of continuous bed motion acquisition on a preclinical digital PET/CT system: Monte Carlo simulation and experimental measurements

  • 期刊论文

  • 发表日期：

    2026年5月10日

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  • Xinyu Li,
  • Xiangye Su,
  • Yu Liu,
  • Dengyun Mu,
  • Wentao Hu,
  • Yang Liu,
  • Peng Xiao

摘要

Purpose:

Most preclinical positron emission tomography (PET) systems are designed for small-animal imaging and offer a limited axial field of view (FOV). The step-and-shoot (S&S) acquisition mode is employed for whole-body imaging of larger animals. However, the reduced axial sensitivity at the edges of the FOV may lead to increased noise at the image boundaries. Continuous bed motion (CBM) acquisition mode is an efficient whole-body imaging protocol available on some clinical PET systems. This study aims to evaluate and implement the CBM acquisition mode on the preclinical digital PET/CT system RAYCAN Discoverist 180 (D180) and to compare its performance with the S&S mode.

Methods:

The CBM acquisition mode enables imaging by mapping the normalized events into the virtual system, followed by random and attenuation correction. In addition, the effects of different virtual crystal sizes on image quality were evaluated. The mode was first validated via Monte Carlo simulations and subsequently implemented in the D180 system for real imaging.

Results:

In contrast with the S&S acquisition mode, the CBM acquisition mode demonstrates more consistent axial noise levels. Adjusting the virtual crystal size can improve the axial spatial resolution in CBM acquisition mode while maintaining its benefit in axial noise uniformity.

Conclusion:

The CBM acquisition mode reduces scanning complexity and maintains axial noise uniformity, making it an attractive alternative to the S&S acquisition mode for imaging larger animals in preclinical PET systems.