Background <p>In radiotherapy settings, advancing research on inorganic scintillation dosimeters (ISDs) for ionizing radiation measurement has revealed a widely reported over-response phenomenon during acquisition of percentage depth dose and off-axis ratio curves. This over-response causes significant deviations between readings from inorganic scintillator-based dosimeters and actual delivered doses, resulting in protracted stagnation in the development of such dosimeters for years.</p> Purpose <p>The causes of the over-response phenomenon were analyzed, and a method to overcome this phenomenon was proposed, enabling radiation dosimeters based on inorganic scintillation materials to be used effectively in radiotherapy environments.</p> Methods <p>An embedded radiation dosimeter based on Gd₂O₂S:Tb material has been fabricated to measure percentage depth dose and off-axis ratio curves under various field conditions. Corresponding correction factor curves were obtained by comparing the results with ionization chamber and radiochromic film data. Finally, the reliability of the correction method was verified through experimental validation.</p> Results <p>The correction factor curves for field sizes ranging from 1 × 1 cm² to 10 × 10 cm² were calibrated, and the data measured by the inorganic scintillation dosimeters were corrected using these factors. It was found that the deviation of the target dose after correction did not exceed 3%, provided that the mechanical setup accuracy was ensured.</p> Conclusions <p>This calibration process aims to enable the effective application of inorganic scintillation dosimeters in radiotherapy environments, providing new possibilities for quality control monitoring in radiation therapy.</p>