Purpose <p>The current waveform of fast-pulse power supplies has a significant impact on beam quality and production efficiency in isotope production facilities. Traditional waveform control methods suffer from considerable delays and unreliable data transmission in strong electromagnetic environments, which results in waveform distortion and affects isotope purity. The study aims to develop a waveform data generation method and to support the stable operation of fast-pulse power supplies in medical isotope production.</p> Methods <p>To address these challenges, this paper proposes a rapid waveform data generation method based on Field Programmable Gate Arrays (FPGA), specifically designed for fast-pulse power supplies in accelerator areas. This method integrates linear fitting, nonlinear fitting, optimized Coordinate Rotation Digital Computer (CORDIC) algorithm, and pipelined operations. In practical engineering, it can meet various waveform requirements of fast-pulse power supplies of accelerators.</p> Results <p>The results demonstrate that the waveform generation delay is less than 200&#xa0;ns, and the waveform data distortion level is as low as 10^⁻5. This approach supports the production of arbitrary waveform data to meet the requirements of fast-pulse power supplies for various applications in accelerator facilities. Furthermore, the proposed method is designed for enhanced portability, featuring no platform-specific Intellectual Property (IP) cores and the ability to be configured on any FPGA platform that supports the Verilog hardware description language.</p> Conclusion <p>This paper presents the design concept as well as the principles of the proposed method, demonstrates its compatibility and flexibility, and analyzes its performance. This technical framework also provides a waveform data generation reference for next-generation fast-pulse power supplies of accelerators.</p>