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Background <p>Periodontitis is a multifactorial inflammatory disease primarily caused by a dysbiotic oral biofilm and host-mediated tissue destruction. While scaling and root planing (SRP), with or without laser therapy, is the cornerstone of nonsurgical treatment, recent evidence supports the use of probiotics to reduce inflammation and restore microbial balance.</p> Aim <p>To compare and clinically assess the effectiveness of probiotics as an adjunct in the non-surgical treatment of Stage II, Grade B generalized periodontitis with and without conventional and diode laser-assisted SRP.</p> Materials and methods <p>A randomized, placebo-controlled clinical trial recruited 40 patients with Stage II, Grade B periodontitis. Patients were randomly randomized to undergo either SRP alone (conventional or diode laser-assisted) or SRP plus probiotic supplementation (Vizylac HP capsules with Lactobacillus reuteri DSM 17938). At baseline and four weeks after treatment, clinical measures, including periodontal inflamed surface area (PISA), modified sulcular bleeding index (mSBI), plaque index (PI), gingival index (GI), and probing pocket depth (PPD), were assessed.</p> Results <p>Between baseline and four weeks, both treatment methods demonstrated statistically significant improvements in all clinical measures. However, the groups that received diode laser SRP with probiotics showed higher reductions in PPD, GI, PISA, and mSBI scores than their non-probiotic counterparts.</p> Conclusion <p>Probiotic supplements may provide better clinical effects in the nonsurgical treatment of chronic periodontitis by lowering inflammation and promoting periodontal repair when combined with traditional or laser-assisted SRP.</p>

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Effect of probiotic supplementation as an adjunct to conventional and laser-assisted nonsurgical periodontal therapy: a randomized controlled trial in stage II, grade B patients with generalized periodontitis

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Neeraja Gajula,
  • Divya Kumar,
  • Deepak Moses Ravindran,
  • Dhanadivya Krishnakumar,
  • Muthukumar S,
  • Balaji SK

摘要

Background

Periodontitis is a multifactorial inflammatory disease primarily caused by a dysbiotic oral biofilm and host-mediated tissue destruction. While scaling and root planing (SRP), with or without laser therapy, is the cornerstone of nonsurgical treatment, recent evidence supports the use of probiotics to reduce inflammation and restore microbial balance.

Aim

To compare and clinically assess the effectiveness of probiotics as an adjunct in the non-surgical treatment of Stage II, Grade B generalized periodontitis with and without conventional and diode laser-assisted SRP.

Materials and methods

A randomized, placebo-controlled clinical trial recruited 40 patients with Stage II, Grade B periodontitis. Patients were randomly randomized to undergo either SRP alone (conventional or diode laser-assisted) or SRP plus probiotic supplementation (Vizylac HP capsules with Lactobacillus reuteri DSM 17938). At baseline and four weeks after treatment, clinical measures, including periodontal inflamed surface area (PISA), modified sulcular bleeding index (mSBI), plaque index (PI), gingival index (GI), and probing pocket depth (PPD), were assessed.

Results

Between baseline and four weeks, both treatment methods demonstrated statistically significant improvements in all clinical measures. However, the groups that received diode laser SRP with probiotics showed higher reductions in PPD, GI, PISA, and mSBI scores than their non-probiotic counterparts.

Conclusion

Probiotic supplements may provide better clinical effects in the nonsurgical treatment of chronic periodontitis by lowering inflammation and promoting periodontal repair when combined with traditional or laser-assisted SRP.