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Background <p>Plasma cell granuloma (PCG) is an infrequent benign lesion defined by a localised proliferation of plasma cells; oral involvement is rare and may resemble neoplasia.</p> Case report <p>A 37-year-old male exhibited a painless gingival mass located in the anterior region of the mandible. Clinical examination revealed a reddish-pink pedunculated lesion that exhibited bleeding upon manipulation; radiographic assessment indicated the absence of bone loss. After Phase I periodontal therapy, the lesion was excised using a diode laser. Histopathological analysis indicated a predominance of plasma cells in the chronic inflammatory infiltrate, while immunohistochemical assessment revealed polyclonality (kappa and lambda) alongside positive CD38/CD138, thereby confirming the diagnosis of PCG. The healing process was unremarkable, with no recurrence observed at the six-month mark.</p> Conclusion <p>Diode-laser excision achieved precise excision, reliable haemostasis, and comfortable recovery in a uncommon gingival PCG. While surgical excision is standard, this minimally invasive approach is a practical alternative in suitable soft-tissue cases.</p>

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Minimally invasive management of gingival plasma cell granuloma using a 445 nm diode laser: a clinical case report

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Amanurrahman Zubair Ahemad,
  • Mehak Gupta,
  • Lata Goyal,
  • Manjit Kaur Rana

摘要

Background

Plasma cell granuloma (PCG) is an infrequent benign lesion defined by a localised proliferation of plasma cells; oral involvement is rare and may resemble neoplasia.

Case report

A 37-year-old male exhibited a painless gingival mass located in the anterior region of the mandible. Clinical examination revealed a reddish-pink pedunculated lesion that exhibited bleeding upon manipulation; radiographic assessment indicated the absence of bone loss. After Phase I periodontal therapy, the lesion was excised using a diode laser. Histopathological analysis indicated a predominance of plasma cells in the chronic inflammatory infiltrate, while immunohistochemical assessment revealed polyclonality (kappa and lambda) alongside positive CD38/CD138, thereby confirming the diagnosis of PCG. The healing process was unremarkable, with no recurrence observed at the six-month mark.

Conclusion

Diode-laser excision achieved precise excision, reliable haemostasis, and comfortable recovery in a uncommon gingival PCG. While surgical excision is standard, this minimally invasive approach is a practical alternative in suitable soft-tissue cases.