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Purpose <p>This randomized controlled clinical trial pilot study aimed to evaluate the effectiveness of Photobiomodulation (PBM) applied to the major salivary glands in individuals with Sjögren’s Syndrome (SS) and the impact of oral health on quality of life (QoL).</p> Methods <p>Patients presenting with hyposalivation or low salivary flow due to SS were recruited, randomized, and allocated into two groups: laser group (LG) and laser plus saliva substitute group (LG/SS). PBM was systematically applied to the participants’ major salivary glands in 16 sessions over a two-month period, using a laser device operating at 780&#xa0;nm and 100 mW. Salivary flow measurements and assessments using the Oral Health Impact Profile (OHIP-14) were performed at baseline (first appointment) and at 1, 2, 3, and 5 months following the initiation of PBM.</p> Results <p>There was a significant increase in both stimulated and unstimulated salivary flow in the groups. This improvement in salivary production was accompanied by a reduction in the negative impact of oral health on QoL, as measured by OHIP-14 scores.</p> Conclusion <p>PBM showed promising trends in increasing salivary flow and contributing to improvement of oral health-related QoL in individuals with SS.</p>

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Influence of photobiomodulation on the major salivary glands in individuals with Sjögren’s syndrome and impact of oral health on quality of life: a pilot study

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Letícia Medeiros Abellaneda,
  • Vinícius Lima Sabbag,
  • Verônica Caroline Brito Reia,
  • Mattheus Augusto Siscotto Tobias,
  • Paulo Sérgio da Silva Santos

摘要

Purpose

This randomized controlled clinical trial pilot study aimed to evaluate the effectiveness of Photobiomodulation (PBM) applied to the major salivary glands in individuals with Sjögren’s Syndrome (SS) and the impact of oral health on quality of life (QoL).

Methods

Patients presenting with hyposalivation or low salivary flow due to SS were recruited, randomized, and allocated into two groups: laser group (LG) and laser plus saliva substitute group (LG/SS). PBM was systematically applied to the participants’ major salivary glands in 16 sessions over a two-month period, using a laser device operating at 780 nm and 100 mW. Salivary flow measurements and assessments using the Oral Health Impact Profile (OHIP-14) were performed at baseline (first appointment) and at 1, 2, 3, and 5 months following the initiation of PBM.

Results

There was a significant increase in both stimulated and unstimulated salivary flow in the groups. This improvement in salivary production was accompanied by a reduction in the negative impact of oral health on QoL, as measured by OHIP-14 scores.

Conclusion

PBM showed promising trends in increasing salivary flow and contributing to improvement of oral health-related QoL in individuals with SS.