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Aim <p>This study aimed to compare the efficacy of photobiomodulation therapy (PBM) and photodynamic therapy (PDT) in treating erythematous and ulcerative oral lichenoid lesions that was not evaluated before.</p> Method <p>In this single-blinded clinical trial study, 10 patients with OLL according to inclusion and exclusion criteria were selected. For one side of mouth PBM with diode 660&#xa0;nm was irradiated and for other side PDT with diode 660&#xa0;nm and methylene blue with the same dose was irradiated. Each patient underwent four treatment sessions over two weeks, followed by a 48 days follow-up. Pain intensity, change in lesion size, clinical improvement by using the Thongprasom scoring system, recurrence of ulcers was evaluated. Statistical analyses were conducted using Friedman, Mann-Whitney, and Chi-square tests.</p> Results <p>Both PBM and PDT demonstrated significant reductions in lesion size, pain intensity, and clinical improvement (<i>p</i> &lt; 0.05). But there was no significant difference for pain reduction, size of lesions, Thongprason scale and recurrence between two methods.</p> Conclusion <p>PBM and PDT are both effective in managing OLL, with neither showing superiority.</p>

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Comparative evaluation of photobiomodulation and photodynamic therapy for management of erythematous and ulcerative oral lichenoid lesions

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • Reyhaneh Rezaei,
  • Amir Mansour Shirani,
  • Bahareh Bagheri Todeshki

摘要

Aim

This study aimed to compare the efficacy of photobiomodulation therapy (PBM) and photodynamic therapy (PDT) in treating erythematous and ulcerative oral lichenoid lesions that was not evaluated before.

Method

In this single-blinded clinical trial study, 10 patients with OLL according to inclusion and exclusion criteria were selected. For one side of mouth PBM with diode 660 nm was irradiated and for other side PDT with diode 660 nm and methylene blue with the same dose was irradiated. Each patient underwent four treatment sessions over two weeks, followed by a 48 days follow-up. Pain intensity, change in lesion size, clinical improvement by using the Thongprasom scoring system, recurrence of ulcers was evaluated. Statistical analyses were conducted using Friedman, Mann-Whitney, and Chi-square tests.

Results

Both PBM and PDT demonstrated significant reductions in lesion size, pain intensity, and clinical improvement (p < 0.05). But there was no significant difference for pain reduction, size of lesions, Thongprason scale and recurrence between two methods.

Conclusion

PBM and PDT are both effective in managing OLL, with neither showing superiority.