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<p>The BL18U1 microcrystallographic beamline at the Shanghai Synchrotron Radiation Facility (SSRF) is one of the five beamlines operated by the National Facility for Protein Science in Shanghai (NFPSS), and is the first microcrystallographic beamline at a third-generation synchrotron light source in China. The beamline uses a U25 undulator as its source and provides a tunable energy range from 5 to 18&#xa0;keV. BL18U1 is specifically designed for collecting diffraction data from protein crystals as small as 10&#xa0;µm in diameter, with the X-ray beam focused to below <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(10\,\upmu\text{m} \times 10\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mn>10</mn> <mspace width="0.166667em" /> <mi mathvariant="normal">μ</mi> <mtext>m</mtext> <mo>×</mo> <mn>10</mn> </mrow> </math></EquationSource> </InlineEquation><InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(\upmu\text{m}\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi mathvariant="normal">μ</mi> <mtext>m</mtext> </mrow> </math></EquationSource> </InlineEquation> while maintaining a high photon flux. The experimental station is equipped with a high-precision MD2 diffractometer, a Pilatus 3-6M single-photon-counting hybrid pixel detector, and a Rigaku ACTOR robotic sample changer. Together, these integrated systems provide an efficient and user-friendly platform for data collection, enabling routine acquisition of high-quality diffraction data from challenging microcrystals and supporting a broad range of macromolecular crystallography experiments.</p>

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The protein microcrystallography beamline (BL18U1) at the Shanghai Synchrotron Radiation Facility

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Qing-Jie Xiao,
  • Bo Sun,
  • Yi-Jun Gu,
  • Lin Tang,
  • Jian-Chao Tang,
  • Ting-Ting Wu,
  • Kang-Wen Bao,
  • Yu-Pu Zhang,
  • Chun-Yu Li,
  • Lan-Lu Lu,
  • Zhong-Jie Zhu,
  • Luo-Zhen Jiang,
  • Yang Liu,
  • Wei-Zhe Zhang,
  • Shu-Yu Zhou,
  • Jian-Hua He,
  • Wen-Ming Qin

摘要

The BL18U1 microcrystallographic beamline at the Shanghai Synchrotron Radiation Facility (SSRF) is one of the five beamlines operated by the National Facility for Protein Science in Shanghai (NFPSS), and is the first microcrystallographic beamline at a third-generation synchrotron light source in China. The beamline uses a U25 undulator as its source and provides a tunable energy range from 5 to 18 keV. BL18U1 is specifically designed for collecting diffraction data from protein crystals as small as 10 µm in diameter, with the X-ray beam focused to below \(10\,\upmu\text{m} \times 10\) 10 μ m × 10 \(\upmu\text{m}\) μ m while maintaining a high photon flux. The experimental station is equipped with a high-precision MD2 diffractometer, a Pilatus 3-6M single-photon-counting hybrid pixel detector, and a Rigaku ACTOR robotic sample changer. Together, these integrated systems provide an efficient and user-friendly platform for data collection, enabling routine acquisition of high-quality diffraction data from challenging microcrystals and supporting a broad range of macromolecular crystallography experiments.